HIV/HCV共感染对外周血T淋巴细胞亚群及白细胞的影响  

Impact of HIV/HCV coinfection on peripheral T-lymphocyte subsets and white blood cells

作　　者：代建霞[1] 贾海英[1] 王玲玲[1] 王昌敏[1] 黄国虹[1] 

机构地区：[1]新疆维吾尔自治区人民医院临床检验中心,新疆乌鲁木齐830001

出　　处：《中国热带医学》2015年第9期1116-1118,1123,共4页China Tropical Medicine

摘　　要：目的分析HIV/HCV共感染患者外周血T淋巴细胞亚群计数和白细胞检测结果。方法收集41例HIV/HCV共感染患者(共感染组)、62例HIV单纯感染者(单纯感染组)及56例健康体检人员(对照组)的抗凝血,用流式细胞仪技术检测外周血CD4+T及CD8+T淋巴细胞,全自动血细胞分析仪检测白细胞。结果共感染组在性别、年龄上与单纯感染组和对照组差异均有统计学意义(P均<0.05)。CD4+/CD8+、CD4+/CD3+两个项目三组之间比较差异均有统计学意义;CD4+、CD8+、CD4+CD8+、CD8+/CD3+、CD4+CD8+/CD3+、LYMPH六个项目共感染组和单纯感染组与对照组比较差异均有统计学意义(P均<0.05);CD3+、WBC、NEUT三个项目共感染组与对照组比较差异有统计学意义(P均<0.05)。结论 HIV/HCV共感染患者在发病过程中与T淋巴细胞亚群各检测项目及WBC、NEUT、LYMPH密切相关,建议HIV/HCV共感染患者在诊断及治疗过程中定期监测T淋巴细胞亚群计数和白细胞以了解病情的进展及适时进行抗病毒治疗。Objective To analyze the detection result of peripheral T lymphocyte subsets and white blood cells inpatients coinfected with HIV/HCV. Methods Anticoagulant blood from 41 cases coinfected with HIV/HCV（coinfectiongroup）,62 cases with HIV infection（HIV group） and 56 healthy volunteers（control group） were collected and levels of CD4＋Tand CD8＋T lymphocytes were detected by flow cytometry, and the white blood cells in subjects were tested by automatichematology analyzer.Results The gender and age of subjects in coinfection group were significantly different compared tothat of HIV group and control group（P〈0.05）. The CD4＋/CD8＋and CD4＋/CD3＋in patients of three groups were statisticallysignificance. Differences of levels of CD4＋,CD8＋,CD4＋CD8＋,CD8＋/CD3＋,CD4＋CD8＋/CD3＋and LYMPH in cases of coinfectiongroup were significantly different compared to that of HIV groups. Differences of levels of CD3＋,WBC and NEUT in patients ofcoinfection group were statistically significant compared with that of control groups.Conclusion The T lymphocyte subsetscount was closely associated with levels of WBC,NEUT and LYMPH in patients coinfected with HIV/HCV during the diseaseprocess. The counts of T lymphocyte subsets and white blood cells in patients coinfected with HIV/HCV be regularly monitoredduring diagnosis and treatment so as to understand the progression of the disease and execute timely antiviral therapy.

关 键 词：获得性免疫缺陷综合症 丙型肝炎 共感染 T淋巴细胞 白细胞 

分 类 号：R512.91[医药卫生—内科学]