组织声学结构定量技术评价恩替卡韦治疗早期肝硬化的研究  

Evaluating the value of entecavir to the early cirrhosis by acoustic structure quantitative technology

作　　者：姚翀[1] 郑慧[1] 王迪[1] 李晓金[1] 李朝密 万颖[1] 

机构地区：[1]安徽医科大学第一附属医院超声科,合肥230022

出　　处：《安徽医科大学学报》2015年第10期1507-1509,共3页Acta Universitatis Medicinalis Anhui

基　　金：安徽省高校自然科学基金重点项目(编号:KJ2013A166)

摘　　要：目的探讨组织声学结构定量技术(ASQ)评价恩替卡韦治疗早期肝硬化的临床应用价值。方法经过肝脏穿刺活检证实的早期肝硬化患者47例作为实验组,口服恩替卡韦治疗,疗程1年;38例健康志愿者作为对照组。采用ASQ检测对照组、实验组治疗前及治疗后的肝脏,得到其χ2直方图及相关的参数,包括红色及蓝色曲线的均值、众数、标准差及蓝红曲线下面积比值。结果恩替卡韦治疗前,实验组患者χ2直方图曲线较对照组明显增宽、粗糙;蓝色曲线的高度大幅度增加,曲线下的面积增大;红蓝曲线参数较对照组明显增高(P<0.01)。恩替卡韦治疗后,实验组患者曲线发生缩窄并趋向锐利和平滑,蓝色曲线的高度降低,曲线下的面积减小;红蓝曲线的均值、众数及蓝红曲线下面积比值较治疗前降低(P<0.05),但标准差较治疗前无显著变化。结论恩替卡韦能够减轻早期肝硬化患者的肝纤维化程度,ASQ技术对评价恩替卡韦治疗早期肝硬化有一定价值。Objective To evaluate the value of entecavir for the patients with early cirrhosis using acoustic struc-ture quantitative technology. Methods Thirty-eight healthy volunteers（ control group） and forty-seven patients with histologically proved early cirrhosis（ experimental group） were examined by ASQ before the oral treatment of ente-cavir and one year after. The original ultrasonic echo signal of the liver parenchyma was analyzed. The chi-square histogram and relevant parameters （ Red Mode,Red Ave,Red SD,Blue Mode,Blue Ave,Blue SD and BR ratio） were recorded and comparatively analyzed. Results Before the treatment,the red and blue curves of the experi-mental group patients were obviously rougher and broader than the control group,careas under the blue curves of the experimental group were langer too. Statistically significant differences in the parameters were found between the control group and the experimental group（P〈0. 01）. After the treatment,the red and blue curves of the experimen-tal group patients tended to be smooth and sharp, and the area under the blue curve became smaller. The Red Mode,Red Ave,Blue Mode,Blue Ave, and BR ratio were smaller （P〈0. 05）,but not in the Red SD and Blue SD. Conclusion Entecavir can reduce the degree of fibrosis of the early liver cirrhosis. ASQ technique has a certain value for evaluation of entecavir to treat early liver cirrhosis.

关 键 词：组织声学结构定量技术 早期肝硬化 恩替卡韦 

分 类 号：R512.6[医药卫生—内科学]