重症手足口病患儿临床治疗研究  

Clinical study and treatment in children with severe hand,foot and mouth disease

作　　者：高栋[1] 王万鹏[1] 李雪莲[1] 

机构地区：[1]潍坊市人民医院感染性疾病科,山东潍坊261041

出　　处：《中华医院感染学杂志》2015年第19期4519-4521,共3页Chinese Journal of Nosocomiology

基　　金：潍坊市科技发展基金资助项目(201302009)

摘　　要：目的探讨山莨菪碱在重症手足口病循环障碍患儿中的临床疗效,为早期识别和治疗提供临床指导。方法回顾性分析医院2012年5月-2013年9月收治的82例重症手足口病循环障碍患儿临床资料,随机分为治疗组43例和对照组39例,两组患者均给予基础治疗,对照组在基础治疗同时应用米力农治疗,治疗组在以上治疗外加用山莨菪碱治疗,比较两组患儿的临床疗效和临床体征的改善,数据采用SPSS13.0软件进行统计分析。结果患者治疗总有效率治疗组为88.4%、对照组64.1%,两组比较差异有统计学意义(P<0.01);治疗后皮肤苍白湿冷、紫绀、心率增快、血压升高改善率治疗组为92.3%、85.7%、88.5%、91.7%,对照组为62.5%、41.7%、62.5%、45.5%,两组比较差异有统计学意义(P<0.05),血氧饱和度下降、肺部湿啰音改善率治疗组为72.7%、66.7%,对照组为40.0%、40.0%,两组比较差异无统计学意义。结论山莨菪碱能改善重症手足口病循环障碍,早期应用疗效显著。OBJECTIVE To explore the clinical efficacy of Anisodamine in treatment of the cardiovascular dysfunction in child with severe hand ,foot and mouth disease so as to provide guidance for early diagnosis and treatment .METHODS A total of 82 children with the cardiovascular dysfunction of the severe hand ,foot and mouth disease ,who were treated in the hospital from May 2012 to Sep .2013 ,were enrolled in the study and ran‐domly divided into the treatment group with 43 cases and the control group with 39 cases .Then the control group was treated with foundation treatment and Milrinone ,and the treatment group was treated with Anisodamine based on the treatment of the control group .The clinical efficacy and the improvement of clinical signs were ob‐served and compared between the two groups .Statistical analysis was performed with the use of SPSS13 .0 soft‐ware .RESULTS The total effective rate of treatment was 88 .4% in the treatment group and 64 .1% in the control group .The difference between the two groups was significant （P〈0 .01）;the rate of the improvement of clinical signs of the child with pale and clammy skin ,cyanosis ,increased heart rate and drop of blood pressure accounted for 92 .3% ,85 .7% ,88 .5% and 91 .7% respectively in the treatment group and 62 .5% ,41 .7% ,62 .5% and 45 .5% in the control group and the differences were significant （P〈0 .05）;the rate of the improvement of degree of blood oxygen and lung wet rale accounted for 72 .7% and 66 .7% in the treatment group and 40% and 40% in the control group ,the differences were not significant .CONCLUSION Anisodamine can improve the cardiovascular dysfunction in child with severe hand ,foot and mouth disease ,and early diagnosis and treatment can achieve sig‐nificant clinical efficacy .

关 键 词：重症手足口病 循环障碍 山莨菪碱 米力农 

分 类 号：R181.32[医药卫生—流行病学]