清开灵注射液联合盐酸多奈哌齐片治疗阿尔茨海默病临床研究  

Clinical research of treating Alzheimer＆#39;s disease by Qingkailing injection and donepezil hydrochloric

作　　者：张晓东[1] 李敬会[2] 

机构地区：[1]湖北医药学院附属太和医院神经内科,十堰442000 [2]湖北医药学院附属人民医院老年病科,十堰442000

出　　处：《国际中医中药杂志》2015年第10期879-882,共4页International Journal of Traditional Chinese Medicine

摘　　要：目的 评价清开灵注射液联合盐酸多奈哌齐片治疗阿尔茨海默病（Alzheimer＇s disease, AD）的临床疗效.方法 将符合纳入标准的84例AD患者采用随机数字法分为2组各42例.对照组每晚口服盐酸多奈哌齐片5 mg,治疗组在此基础上加用清开灵注射液60 ml静脉滴注,共治疗20周.比较2组治疗前后简易智能量表（mini mental state examination, MMSE）、日常生活活动量表（Activity of daily living scale, ADL）评分;采用放射免疫法检测血清高敏C-反应蛋白（high-sensitivity C-reactive protein, HS-CRP）、白细胞介素-6（interleukin-6, IL-6）、丙二醛（malondialdehyde, MDA）、氧化低密度脂蛋白（oxidized low-density lipoprotein, ox-LDL）含量,评价临床疗效.结果 治疗后,治疗组血清HS-CRP[（4.18± 0.38）mg/L比（5.78±0.53）mg/L,t=15.900]、IL-6[（34.28±4.33）μg/L比（44.75±4.99）μg/L,t=10.270]、MDA[（6.04±0.98）μmol/L 比（7.43±0.69）μmol/L,t=7.516]、ox-LDL[（62.87±7.65）μg/L 比（102.56± 9.81）μg/L , t=26.677]含量均较对照组明显下降（P 均〈0.01）.治疗组、对照组总有效率分别为83.3%（35/42）、61.9%（26/42）,2组比较差异有统计学意义（χ^2=4.850,P=0.028）.治疗组、对照组MMSE评分较同组治疗前升高（t值分别为8.036、7.475,P值均〈0.01）、ADL评分均较同组治疗前降低（t值分别为7.818、5.960,P值均〈0.01）,但2组治疗后比较,差异无统计学意义（t值分别为1.633、1.710,P值分别为0.106、0.091）.结论 清开灵注射液联合盐酸多奈哌齐片可有效降低AD患者血清HS-CRP、IL-6、MDA和ox-LDL含量,疗效优于单纯口服盐酸多奈哌齐片治疗。Objective To observe the clinical treatment effects of Qingkailing injection on Alzheimer＇s disease.Methods 84 patients with AD were randomly divided into a control group and a treatment group （n=42 cases,per group）. The patients in both groups orally took 5 mg of donepezil hydrochloride every night. The Qingkailing injection of 60 ml was administrated by intravenous drip in addition to oral uptake of donepezil hydrochloride to the treatment group. The total treatment period of both groups was 20 weeks. The MMSE, ADL score, HS-CRP, IL-6, MDA and ox-LDL content and the clinical treatment results and differences in the two groups before and after the treatment were observed.Results After treatment, the serum HS-CRP （4.18 ± 0.38 mg/Lvs. 5.78 ± 0.53 mg/L,t=15.900）, IL-6 （34.28 ± 4.33μg/L vs.44.75 ± 4.99μg/L,t=10.270）, MDA （6.04 ± 0.98μmol/L vs.7.43 ± 0.69μmol/L,t=7.516）, ox-LDL （62.87 ± 7.65μg/L vs.102.56 ± 9.81μg/L, t=26.677） content of the treatment group were significantly decreased than the control group （P〈0.01）. The total effective rate between the treatment group and the control group had significance difference （83.3%vs.＆amp;nbsp; 61.9%;χ^2=4.850,P=0.028）. The MMSE score in both groups after the treatment were higher than those in the same group（t value were 8.036, 7.475, respectively,P〈0.01）, ADL scores in both groups after treatment were lower than those before treatment（t value were 7.818, 5.960, respectively,P〈0.01）, but no significance difference between the two groups（t value were 1.633, 1.710,respectively,P value were 0.106, 0.091, respectively）.Conclusion The treatment effect of Qingkailing injection on Alzheimer＇s disease was sound.

关 键 词：阿尔茨海默病 清开灵注射液 中西医结合疗法 简易智能量表 日常生活活动量表 

分 类 号：R969.11[医药卫生—药理学]