饮食及运动干预对高血压伴糖尿病前期患者氧化应激的影响  

The effect of diet and exercise intervention on the oxidative stress of patients with hypertension and pre-diabetes

作　　者：潘巍巍[1] 赵鋆荃[1] 王海滨[1] 

机构地区：[1]青岛市立医院,山东青岛266011

出　　处：《中国预防医学杂志》2015年第9期697-699,共3页Chinese Preventive Medicine

基　　金：青岛市2012年度医药科研指导计划项目(2012-WSZD049)

摘　　要：目的观察饮食及运动干预对高血压伴糖尿病前期患者氧化应激及糖代谢的影响。方法选取76例高血压伴糖尿病前期患者,随机分为干预组和对照组。两组患者药物治疗同前,干预组给予低热量、低钠饮食、控制烟酒摄入等生活干预,并每日增加中等强度运动训练,为期12个月。结果通过12个月的饮食及运动干预,干预组和对照组比较结果显示:体质指数[(21.3±5.6)kg/m2 vs(24.8±6.1)kg/m2]、收缩压[(135.9±6.7)mm Hg vs(142.1±5.2)mm Hg]、舒张压[(81.7±6.2)mm Hg vs(85.1±4.9)mm Hg]降低,血清丙二醛[(7.5±1.5)μmol/L vs(8.2±1.3)μmol/L]降低,超氧化物歧化酶[(98.7±10.8)U/ml vs(87.1±14.2)U/ml]、一氧化氮[(81.7±14.2)μmol/L vs(71.8±13.3)μmol/L]含量升高,空腹血糖[(4.90±1.92)mmol/Lvs(6.50±2.48)mmol/L]、餐后2h血糖[(7.63±3.72)mmol/Lvs(9.73±2.63)mmol/L]、糖化血红蛋白[(4.78±2.54)%vs(6.12±1.68)%]降低,P均<0.05。结论饮食及运动干预能降低高血压伴糖尿病前期患者体质指数、血压,还能改善患者氧化应激及糖代谢异常,可以预防、延缓糖尿病的发生。Objective To discuss the effect of diet and exercise intervention on the oxidative stress of patients with hypertension and pre-diabetes. Methods Seventy-six patients with hypertension and pre-diabetes were randomly divided into two groups.Patients in the intervention group had diet with low calorie and low salt,plus medium level exercise for 12 months besides drug therapy,while patients in control group were only treated with drugs. Results After 12 months of diet and exercise intervention,compared with patients in control group,the body mass index,systolic pressure and diastolic pressure,serum malondialdehyde level as well as FBG,2-hour post-meal blood glucose and glycated hemoglobin of patients in intervention group were all significantly lower [（21.3±5.6）vs（24.8±6.1）kg/m2;（135.9±6.7）vs（142.1±5.2）mm Hg;（81.7±6.2）vs（85.1±4.9）mm Hg;（7.5±1.5）vs（8.2±1.3）μmol/L;（4.90±1.92）vs（6.50±2.48）mmol/L;（7.63±3.72）vs（9.73±2.63）mmol/L;（4.78%±2.54%）vs（6.12%±1.68 %）（P〈0.05）].While,superoxide dismutase and nitric oxide activity increased greatly after the intervention[（98.7±10.8）vs（87.1±14.2）U/ml;（81.7±14.2）vs（71.8±13.3）μmol/L,P〈0.05）]. Conclusions Diet and exercise intervention may reduce the body mass index and decrease blood pressure of patients with hypertension and pre-diabetes,and relieve oxidative stress and glycometabolism abnormity,as well as the prophylaxis of diabetes.

关 键 词：高血压 糖尿病前期 饮食及运动干预 氧化应激 

分 类 号：R587.1[医药卫生—内分泌]