右美托咪定在血管外科介入手术麻醉中的应用  

Application of Dexmedetomidine in Vascular Surgery Interventional Therapy

作　　者：崔敏[1] 叶红[2] 孟丽巍[1] 袁振红[1] 张云安[1] 

机构地区：[1]哈尔滨医科大学附属第一医院麻醉科,黑龙江哈尔滨150001 [2]大庆油田总医院麻醉科,黑龙江大庆163000

出　　处：《现代生物医学进展》2015年第23期4487-4489,共3页Progress in Modern Biomedicine

基　　金：黑龙江省教育厅科学技术研究项目(12531315)

摘　　要：目的:探讨靶控输注不同浓度右美托咪定对血管外科介入手术的效果。方法:选择周围血管疾病成年患者60例,随机分为I、II、III三组,每组20例。各组右美托咪定靶控输注浓度分别为0.2μg/kg/h,0.3μg/kg/h和0.4μg/kg/h,术中监测并记录各组手术开始前(T1),手术开始10 min(T2),手术开始30 min(T3),手术开始60 min(T4)四个时间点的平均动脉压(MAP),心率(HR),血氧(Sp O2),脑电双频指数(BIS)。结果:T2、T3、T4时平均动脉压Ⅰ组与Ⅱ组比较P<0.05,Ⅰ组与Ⅲ组比较P<0.05。T2时Ⅲ组与Ⅰ、Ⅱ组比较P<0.05,T3、T4时Ⅱ、Ⅲ组与Ⅰ组比较均P<0.05。结论:右美托咪定靶控输注浓度为0.3μg/kg/h和0.4μg/kg/h时,对血管外科介入手术能产生良好的镇静作用,并且可保证术中循环的稳定。Objective： To study the effects of different target controlled infusion（TCI） rates of dexmedetomidine on interventional therapy in vascular surgery. Methods： 60 patients with peripheral vascular disease were selected and randomly divided into 3 groups（I, II and III, n=20）. The infusion rate of dexmedetomidine for each group was 0.2, 0.3, and 0.4 μg/kg/h, respectively. MAP, HR, Sp O2 and BIS were monitored at four time points： before surgery（T1）, 10 min, 30 min and 60 min after surgery（T2-T4）. Results： Significant difference（P〈0.05） of MAP between group I and II, group I and III was observed at T2-T4. Meanwhile, significant difference of HR between group I and III at T2-T4, group I and II at T3/T4, group II and III at T2 was also found. Conclusion： TCI rates of dexmedetomidine at both 0.3 and 0.4 μg/kg/h can exert good sedative effect on interventional therapy in vascular surgery, and assure satisfactory intraoperative analgesia at the same time.

关 键 词：右美托咪定 血管外科 介入手术 镇静 

分 类 号：R614[医药卫生—麻醉学]