36h睡眠剥夺对事件相关电位N270影响的对照研究  

A Control Study of Event Related Potential N270 in 36 h Sleep Deprivation

作　　者：廖春华[1] 刘朝晖[1] 魏莹[1] 辛蔚[1] 张茜茹[1] 

机构地区：[1]第四军医大学唐都医院,陕西西安710038

出　　处：《现代生物医学进展》2015年第23期4498-4501,共4页Progress in Modern Biomedicine

基　　金：兰州军区医药卫生科研项目(LXH-2009002)

摘　　要：目的:应用事件相关电位技术探讨36 h完全睡眠剥夺对认知功能的影响。方法:9名健康被试参加36h睡眠剥夺试验,被试在36 h睡眠剥夺前后分别接受数字-符号联想测验,同时记录其事件相关电位,分析其在睡眠剥夺前后认知功能的动态变化情况。结果:1被试在睡眠剥夺前后的反应时相比[(748.16±193.27)与(775.79±205.48)ms],显著增加(t=3.86,P<0.05),正确率相比[(74.56±0.11)与(67.12±0.07)],没有显著性差异(P>0.05)。2被试在睡眠剥夺36 h后,P3、P4、C3和C4四点潜伏期没有显著性变化[P3:(296.44±16.61)与(300.22±16.16)ms,t=1.43,P=0.19;P4:(303.33±38.48)与(308.78±38.65)ms,t=2.35,P=0.05;C3:(309.56±34.09)与(308.44±28.49)ms,t=0.45,P=0.66;C4:(317.33±64.83)与(303.33±39.42)ms,t=1.31,P=0.23],四点波幅降低,且差异具有统计学意义(P<0.05)[P3:(2.74±1.21)与(1.32±0.92)μv,t=2.54,P=0.04;P4:(2.34±1.27)与(0.94±0.49)μv,t=3.44,P=0.01;C3:(2.60±1.49)与(0.94±0.78)μv,t=2.65,P=0.03;C4:(2.60±0.81)与(1.11±1.03)μv,t=2.61,P=0.03]。结论:睡眠剥夺影响人的正常认知活动,损害了大脑对冲突信息的判断,睡眠对维持大脑的正常功能有重要作用。Objective： To explore the effect of 36 h sleep deprivation on the cognition of the brain. Methods： 9 healthy subjects were detected with the ERP after 36 h sleep deprivation. The changes of cognition and function of the brain were analyzed. Results： 1The reaction time of subjects was significantly longer after 36 h sleep deprivation（t=3.86, P〈0.05）. The correction rate did not show significant difference（P〉0.05）. 2The latency at P3, P4, C3 and C4 of subjects did not show significant difference. The amplitude at P3,P4, C3, C4 significantly lowered after 36 h sleep deprivation（P〈0.05）. Conclusion： Sleep deprivation affects the cognition of individuals and sleep plays an important role in maintenance of normal function of the brain.

关 键 词：睡眠剥夺 认知功能 事件相关电位 N270 

分 类 号：B849[哲学宗教—应用心理学]