糖尿病肾病患者血浆基质金属蛋白酶-2和同型半胱氨酸水平及其临床意义  

Analysis of Test Results of Diabetic Nephropathy Patients Plasma Matrix Metalloproteinase-2 and Homocysteine

作　　者：曹雪峰[1] 刘春荣[1] 周秀艳[1] 张燕[2] 白华[3] 

机构地区：[1]河北省唐山市人民医院检验科,河北唐山063000 [2]唐山市传染病医院检验科,河北唐山063000 [3]河北联合大学附属医院内分泌科,河北唐山063000

出　　处：《现代生物医学进展》2015年第25期4916-4918,5000,共4页Progress in Modern Biomedicine

基　　金：唐山市科技局科研项目(13130274b);国家自然科学基金项目(30672763)

摘　　要：目的:探讨糖尿病肾病患者血浆基质金属蛋白酶-2和同型半胱氨酸水平及其临床意义。方法:选取糖尿病患者71例,其中并发糖尿病肾病组(n=35)和未并发肾病组(n=36),同时选取健康人群40例为对照组。检测患者MMP-2、Hcy、MAU及Scr水平。结果:糖尿病肾病组、糖尿病无肾病组血浆MMP-2、Hcy及MAU水平均显著高于健康对照组(P<0.01);与糖尿病无肾病组比较,糖尿病肾病组患者MMP-2、Hcy及MAU水平较高(P<0.05);糖尿病肾病组患者的血浆SCr水平明显高于其他两组(P<0.05)。糖尿病肾病患者血浆MMP-2与MAU呈显著正相关(r=0.522,P<0.05),与Hcy呈显著负相关(r=-0.007,P<0.05),与Scr不相关(P>0.05);Hcy与MAU(r=0.012,P<0.05)、Scr均(r=0.031,P<0.05)呈正相关。结论:糖尿病肾病患者MMP-2水平降低,Hcy水平升高,有望作为糖尿病肾病患者的诊断和预后预测参考指标。Objective： To investigate the changes of plasma matrix metalloproteinase-2（MMP-2） and homocysteine（Hcy） in diabetic nephropathy diagnosis value. Methods： 71 cases of patients with diabetes were selected, which complicated with diabetic nephropathygroup（n=35） and non diabetic nephropathy group（n=36）, and selecting the healthy people in our hospital outpatient department of internal medicine examination in 40 cases as control group. MMP-2 and Hcy levels in patients were detected, the simultaneous detection of MAU, Scr, and the testing results are statistical analysis. Results： Hcy, plasma MMP-2 and MAU levels of diabetic nephropathy group, diabetes nephropathy group were significantly higher than those in healthy control group（P〈0.01）, MMP-2and MAU levels of diabetic nephropathy group were higher than without nephropathy group（P〈0.01）. The plasma SCr level in patients with diabetic nephropathy group were significantly higher than the other two groups（P 〈 0.05）; According to the correlation analysis,Diabetic nephropathy patients with positive plasma MMP-2 MAU and SCr, and negatively correlated with Hcy. Conclusion： MMP-2 and Hcy decreased gradually with the MMP-2 level of diabetic nephropathy, Hcy levels increased gradually. Diabetic nephropathy patients MMP-2, MAU, plasma Hcy and Scr were correlated, suggesting that renal function in patients with diabetes increased with aggravation of diabetes, has guiding significance for clinical.

关 键 词：糖尿病肾病 同型半胱氨酸 基质金属蛋白酶-2 

分 类 号：R587.2[医药卫生—内分泌]