血肌酐与非ST段抬高急性冠脉综合征冠脉病变程度及其预后  

Influence of Serum Creatinine on Severity of Coronary Artery Lesions and its Prognosis in patients with Non-ST-elevation Acute Coronary Syndrome

作　　者：李阳[1,2] 左波[3] 李屾[4] 季汉华[1,2] 

机构地区：[1]北京大学民航临床医学院 [2]民航总医院,北京100123 [3]北京大学人民医院,北京100044 [4]山东大学第二医院,山东济南250033

出　　处：《现代生物医学进展》2015年第26期5098-5102,共5页Progress in Modern Biomedicine

摘　　要：目的:研究血清肌酐(serum creatinine,SCr)与非ST段抬高急性冠脉综合征(non-ST-elevation acute coronary syndrome,NSTE-ACS)患者冠脉病变程度及其预后的关系。方法:对293例患者进行回顾性分析,依据冠脉造影结果分为NSTE-ACS组和非冠心病组。根据Gensini积分系统,评价NSTE-ACS患者冠脉病变程度,并将患者分为轻度病变组、中度病变组和重度病变组。检测患者SCr水平,应用SPSS16.0分析SCr与NSTE-ACS患者冠脉病变程度及其预后关系。结果:(1)与非冠心病组相比,NSTE-ACS患者SCr较高(P<0.05);其中,重度冠脉病变NSTE-ACS患者SCr水平尤高(P<0.001)。(2)SCr是NSTE-ACS冠脉病变的危险因子;SCr与NSTE-ACS冠脉病变程度呈正相关(r=0.263,P<0.000);SCr与NSTE-ACS主要心血管不良事件(Major Adverse Cardiovascular Events,MACE)呈正相关(r=0.183,P<0.01)。结论:SCr是NSTE-ACS患者冠脉病变的独立危险因子,且与NSTE-ACS患者预后相关。SCr对于NSTE-ACS的诊疗有潜在临床价值。Objective： To explore the correlation between the severity of coronary artery lesion, its prognosis and serum creatinine （SCr） in patients with non-ST-elevation acute coronary syndrome（NSTE-ACS）. Methods： A total of 293 hospitalized patients undergoing coronary angiography with NSTE-ACS were selected in this retrospective study, including patients with NSTE-ACS and normal coronary arteries. The extent and severity of coronary artery lesions is evaluated by Gensini system. Patients With NSTE-ACS were divided into three groups： high lesion group, mild lesion group and low lesion group. SCr was measured and SPSS was used to analyze relation be- tween the severity of coronary artery lesion, its prognosis and SCr in patients with NSTE-ACS. Results： （1） SCr was higher in patients with NSTE-ACS than that in control group （P〈0.05）; SCr was higher in high lesion group than that in other groups（P〈0.01）. （2） SCr is an independent risk factor for coronary artery lesion in patients with NSTE-ACS （P〈0.05）and had significant correlation with it （r=0.263, P〈0.000）. SCr also had significant correlation with Major Adverse Cardiac Event（MACE） in NSTE-ACS（r=0.183, P〈0.01）. Conclusion： SCr is an independent risk factor for coronary artery lesion and is correlated with prognosis in NSTE-ACS. SCr has potential value for di- agnosis and treatment of NSTE-ACS.

关 键 词：非ST段抬高 急性冠脉综合征 血清肌酐 危险因子 预后 

分 类 号：Q51[生物学—生物化学]