丹红注射液对急性冠脉综合征患者血浆脑钠肽及心率变异性的影响  

Effect of Danhong Injection on the Plasma Brain Natriuretic Peptide Level and Heart rate Variability of Patients with Acute Coronary Syndrome

作　　者：刘铁楠[1] 吴春涛[1] 周云会 李素新[1] 白华[1] 

机构地区：[1]河北联合大学附属医院心内科,河北唐山063000

出　　处：《现代生物医学进展》2015年第26期5122-5125,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨丹红注射液对急性冠脉综合征患者血浆脑钠肽水平及心率变异性的影响。方法:选取我院收治的急性冠脉综合征患者72例,并将其随机分为实验组和对照组。对照组36例,予以阿司匹林肠溶片100 mg/日一次口服、低分子肝素钠200 IU/kg体重,每日一次皮下注射及普萘洛尔20 mg/日3次口服等常规治疗,2周为一个疗程,治疗两个疗程;实验组36例,在常规治疗的基础上加用丹红注射液,30 m L,加入5%葡萄糖注射液250 m L滴注,每日二次,2周为一个疗程,治疗两个疗程。治疗结束后,比较治疗前后两组患者的血浆脑钠肽水平及心率变异性中SDNN、SDANN、RMSSD、PNN50%变化。结果:1治疗后,两组患者血浆脑钠肽水平均有所改善,且实验组血浆脑钠肽(96.72±19.43 ng/L)较对照组血浆脑钠肽(147.53±26.89 ng/L)明显下降,差异有统计学意义(P<0.05);2治疗后,两组患者心率变异性中SDNN、SDANN、RMSSD、PNN50%各指标均有所改善,且实验组改善情况明显优于对照组,差异有统计学意义(P<0.05)。结论:丹红注射液能够明显降低急性冠脉综合征患者的血浆脑钠肽水平,并显著改善心率变异性各项参数,从而可能有助于改善记性冠脉综合征患者的预后。Objective： To investigate Danhong injection on the plasma brain natriuretic peptide level and heart rate variability of patients with acute coronary syndrome （ACS）. Methods： 72 cases of patients with ACS admitted in the departemt of circulation of our hospital were selected and randomly divided into the control group and experiment group. 36 cases in the control group were given westem medicine preparations, anticoagulant, antithrombotic, anti-arrhythmic agents regular treatment, 2 weeks for a period of treatment, two courses of treatment. 36 cases in the the experimental group were treated by Danhong injection on the basis of conventional treatment, 30 ml, add 5% glucose injection 250 mL drip, 2 times a day, 2 weeks for a period of treatment, two courses of treatment. After the treatment, the plasma brain natriuretic peptide levels and heart rate variability SDNN, SDANN, RMSSD, PNN50 % were compared between two groups before and after treatment. Results： ①Tbe plasma brain natriuretic peptide levels in both groups after treatment were improved, and the average plasma brain natriuretic peptide （96.72 ng/L） of experimental group was significantly lower than that of the control group （147.53 ng/L）, the difference was statistically significant （P〈0.05）; ②The heart rate variability SDNN, SDANN, RMSSD, PNN50 % of each index were improved in both groups, and the experimental group was more obviously improved than the control group, the difference was statistically significant （P〈0.05）. Conclusion： Danhong injection could obviously decrease the plasma brain natriuretic peptide level of patients with ACS, and significantly improve the heart rate variability, which could contribute to improve the prognosis of ACS.

关 键 词：丹红注射液 急性冠脉综合征 脑钠肽 心率变异性 

分 类 号：R541.4[医药卫生—心血管疾病] R285.5[医药卫生—内科学]