系统性红斑狼疮患者发生狼疮性肾炎与年龄和自身抗体谱的相关性分析  

Relationship between autoantibody profiles,age and occurrence of LN

作　　者：袁红[1] 曾雪曦 

机构地区：[1]四川省医学科学院四川省人民医院检验科,四川成都610072

出　　处：《国外医学（医学地理分册）》2015年第3期218-221,共4页Foreign Medical Sciences：Section of Medgeography

摘　　要：目的探究系统性红斑狼疮(systemic lupus erythematosus,SLE)患者并发狼疮性肾炎(lupus nephritis,LN)的年龄和自身抗体谱特征,比较LN和原发性肾小球肾炎(Primary Glomerulonephritis,PGN)患者补体C3和其它肾脏损伤指标的变化差异。方法回顾性分析2012—2013年四川省人民医院LN患者和非LN的SLE患者的ANA、抗ds-DNA、抗Sm、抗SSA、抗SSB等自身抗体的阳性率及LN患者的年龄分布情况;比较LN、PGN患者补体C3的改变及与Urea、Cr、UA、尿蛋白、尿常规结果的关系。结果自身抗体检测结果比较,仅抗ds-DNA抗体在LN组(48.72%)和非LN组(32%)间有统计学差异(P<0.05);LN年龄分布情况比较,只有≥51岁的LN组(7.79%)和非LN组(19%)具有统计学差异(P<0.05);LN和PGN患者不同程度表现出补体C3下降,以LN更为明显(P<0.05),LN生化异常发生率明显高于PGN(P<0.01),而两者之间尿常规异常发生率则没有明显差异(P>0.05)。结论 30岁以下、抗ds-DNA抗体阳性的SLE患者更容易发生LN,并提示肾脏功能预后较差;狼疮性肾炎患者C3下降较原发性肾小球肾炎更为明显(P<0.05),肾功能损害程度也明显高于原发性肾小球肾炎患者。Objective To explore the characteristics of autoantibody profiles and age distribution among SLE patient complicated with lupus nephritis （LN） and to compare the changes in C3 and other renal injuries between LN and primary glomerulonephritis （PGN） .Methods We retrospectively reviewed the positive rates of AnuA ,anti‐ds‐DNA ,anti‐Sm ,anti‐SSA ,anti‐SSB and other autoantibodies among SLE patients with and without LN treated in Sichuan Provincial People’s Hospital during 2012 to 2013 ,and the age distribution of LN patients ,compared the changes in C3 ,LN and PGN ,and analyzed their relationships with the results of Urea ,Cr ,UA ,urinary protein and urine routine test among LN patients and PGN patients .Results Autoantibodies examination results showed that only the anti‐ds‐DNA antibody had statistical difference （P〈0 .05） between LN group （48 .72% ） and non‐LN group （32% ）;the age distribution of LN patients showed that statistical difference （P〈0 .05） only existed between LN group （7 .79% ） and non‐LN group （19% ） above 50 years old;the reduction in C3 varied among LN and PGN patients while more evident change in C3 was observed among LN patients . The incidence of biochemical manifestations was higher among LN patients as compared to PGN patients （P〈0 .01） ,but no distinct difference in the incidence of abnormal urine test results was found between LN and PGN patients .Conclusions LN is more likely to occur in SLE patients who are anti‐ds‐DNA antibody positive and younger than 30 years , with poor prognosis of kidney function .The decrease in C3 is more obvious among LN patients as compared to PGN patients （P〈0 .05） ,and damage on kidney function is more serious among LN patients as compared to PGN patients .

关 键 词：狼疮性肾炎 SLE 年龄 PGN 

分 类 号：R512[医药卫生—内科学]