真武通脉汤治疗脾肾阳虚型糖尿病肾病临床观察  

Clinical Observation on Zhenwu Tongmai Decoction on Spleen-kidney Yang Deficiency of Type 2 Diabetic Nephropathy

作　　者：蓝元隆[1] 苏小惠[1] 洪杨华 刘雪娜[1] 方镇福 黄连河 施兆明 戴秀娟[1] 罗金国[1] 刘垠浩 陈丽贞[1] 戴舜珍[1] 

机构地区：[1]福建省漳州市中医院,福建漳州363000

出　　处：《云南中医学院学报》2015年第5期65-69,共5页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：福建中医药大学校管课题项目(XB2012047);福建中医药大学校管课题项目(XB2012044);国家中医药管理局2011年全国名老中医传承工作室建设项目(国中医药人教发[2011]4)

摘　　要：目的观察真武通脉汤治疗脾肾阳虚型糖尿病肾病(Ⅳ期)患者的临床疗效。方法将脾肾阳虚型糖尿病肾病(Ⅳ期)患者65例随机分为对照组(34例)和治疗组(31例),治疗组在对照组常规治疗的基础上加用真武通脉汤,观察治疗前后血压、血糖、血脂、血电解质、血肌酐、晨尿微量白蛋白等。结果治疗后治疗组中舒张压、空腹血糖、胆固醇、甘油三酯、晨尿微量白蛋白明显低于对照组(P<0.05);与治疗前比较,治疗组高密度脂蛋白明显升高(P<0.05),对血肌酐的影响略逊于对照组;治疗组的症状积分改善程度和临床总有效率优于对照组(P<0.05)。结论真武通脉汤改善脾肾阳虚型糖尿病肾病(Ⅳ期)患者危险因素,改善临床症状,提高临床疗效。Objective To investigate the influence of spleen-kidney yang deficiency in type 2 diabetic nephropathy patients by Zhenwu Tongmai decoction. Methods 65 Spleen-kidney yang deficiency of type 2 diabetic nephropathy（4 stage） patients were randomly assigned to two groups. Patients in the control group（n=34）were given conventional antidiabetic treatment,patients in the treatment group（n =34） plus Zhenwu Tongmai decoction. 8 weeks after treatment,the changes of blood pressure,blood glucose,blood lipids,blood electrolytes,Serum creatinine（Scr）,morning micro urinary albumin（UMA）,TCM syndrome,and symptom scores and clinical efficacy were observed. Results After intervention,in treated groups,diastolic pressure（DBP）,fasting plasma glucose（FBG）,cholestero（lTC）,triglyceride（TG）,UMA were significantly decreased compared with the control group（P 0.05）,compared with before treatment,high density lipoprotein cholesterol（HDL） were significantly increase in treated group（P〈0.05）.Serum creatinine was less significantly decreased compared with the control group. After treatment,symptom scores decreased in both two groups compared with before treatment（P〈0.01）,and both of them in treated group were better than in control group（P〈0.05）.Conclusion Zhenwu Tongmai decoction had better effect on improving risk factors in spleen-kidney yang deficiency of type 2diabetic nephropathy patients. and improved the clinical symptoms and overall efficiency of clinical treatment.

关 键 词：真武通脉汤 2型糖尿病 糖尿病肾病 脾肾阳虚 

分 类 号：R255.4[医药卫生—中医内科学]