归脾汤加减联合铁剂治疗早产儿贫血的临床研究  

The Clinical Research of Using Jiajian Guipi Decoction and Chalybeate in Combination to Treat Anemia of Prematurity

作　　者：韩晓[1] 张晓[2] 韩光玺 施春燕[2] 董勤[1] 

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]浙江萧山医院,浙江杭州311121

出　　处：《云南中医学院学报》2015年第5期70-73,共4页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：萧山区科技计划项目(2012448)

摘　　要：目的探讨归脾汤加减联合铁剂的治疗方法对早产贫血患儿血红蛋白、网织红细胞计数和中医证候的影响。方法根据纳入和排除标准,采用便利抽样法在小儿科门诊筛选81名心脾两虚型早产贫血患儿,并按随机数字表法分为治疗组42名和对照组39名。治疗组在口服蛋白琥珀酸铁口服液的基础上联用归脾汤加减治疗,对照组仅接受常规蛋白琥珀酸铁口服液口服,每组均治疗3个疗程,每个疗程4周,在干预前和每个疗程结束后评估患儿血红蛋白、网织红细胞计数和中医证候积分。结果治疗组治疗8周和12周后血红蛋白较对照组升高(P<0.05);治疗组和对照组的网织红细胞计数均在治疗4周后达高峰但治疗组上升程度高于对照组(P<0.01),随后缓慢下降(P>0.05);治疗组治疗12周后中医证候积分较对照组降低(P<0.05);治疗组和对照组治疗后的血红蛋白、网织红细胞计数和中医证候积分均较治疗前改善(P<0.05)。结论归脾汤加减联合铁剂治疗具有纠正早产儿贫血、改善机体一般状况的作用,可用于早产儿贫血的治疗。Objective To observe the effects of Jiajian Guipi decoction combined chalybeate on the hemoglobin,reticulocyte count and TCM syndrome of anemia of prematurity. Methods Based on the inclusive and exclude criteria,81 anaemic prematurity with heart-spleen deficiency syndrome at the pediatric clinic were chosen through convenient sampling and divided into treatment group and control group via a random number table. Treatment group had 41 children and control group had 39 children. Treatment group received Jiajian Guipi decoction therapy based on chalybeate cure,control group only received chalybeate cure. All cases had3 courses of treatment and every course had 4 weeks. The hemoglobin,reticulocyte count and TCM syndrome were evaluated before the treatment and after every course finished. Results After 8 weeks and 12 weeks of the treatment,the hemoglobin of treatment group was increased when compared with control group（P〈0.05）. The reticulocyte count of both treatment group and control group reached their peak after 4 weeks＇ treatment,but the rising range of treatment group was higher than control group（P〈0.01）,then declined slowly（P〈0.05）. After 12 weeks of the treatment,the TCM syndrome of treatment group was increased when compared with control group（P 0.05）. The hemoglobin,reticulocyte count and TCM syndrome of two groups had all improved when compared between before and after the treatment in intra-group（P 0.05）. Conclusion The therapy of Jiajian Guipi decoction combined chalybeate had the curative effect on anemia of prematurity,which could be used as an efficient approach to treat anemia of prematurity.

关 键 词：归脾汤 早产儿 贫血 心脾两虚型 临床观察 

分 类 号：R272[医药卫生—中医儿科学]