免疫毒素的优化设计与制备  

The Optimal Design and Preparation Methods of Immunotoxins

作　　者：吴水发 谢捷明[1] 邓翠敏[1] 王金海[2] 

机构地区：[1]福建医科大学药学院药理学系,福州350108 [2]福建卫生职业技术学院,福州350101

出　　处：《海峡药学》2015年第9期5-9,共5页Strait Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(No 30772587);福建省自然科学基金资助项目(No C0510012;2011J01188);福建医科大学项目(NoJS14011;2013JY018)

摘　　要：目的探讨免疫毒素设计的新思路以及制备方法。方法通过分析传统免疫毒素的结构,总结免疫毒素的研究进展,以及本课题组的实验探究等方法来进行免疫毒素的设计与制备。结果免疫毒素可通过多种方法来进行优化设计,常用的制备方法有化学偶联法及基因工程融合法。结论免疫毒素作为恶性肿瘤的靶向治疗已取得一定的发展,因此对免疫毒素进行优化设计显现出极大的应用前景。OBJECTIVE To explore new designing approaches and preparation methods of immunotoxins.METHODS To study the design and preparation methods by analysing the traditional structure of the immunotoxins,summarizing the research development of immunotoxins ,as well as our own experiment studying.RESULTS Immunotoxins can be optimal designed by various methods which include the chemical coupling method and genetic engineering fusion.CONCLUSION Immunotoxins as a new targeted drug for cancer therapy has made a certain development.The optimal design of immunotoxins displays large application perspective.

关 键 词：免疫毒素 设计 制备 靶向治疗 

分 类 号：TQ460.4[化学工程—制药化工] R979.1[医药卫生—药品]