自制槿柏洗剂治疗头皮脂溢性皮炎的研究  

Study on treatment of seborrheic dermatitis of scalp by homemade Jin Bai Lotion

作　　者：付蓉[1] 李元文[1] 周志强[1] 张丰川[1] 赵凤珠[1] 

机构地区：[1]北京中医药大学东方医院,北京100078

出　　处：《现代中西医结合杂志》2015年第30期3328-3330,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：北京中医药大学临床自主创新课题(2011JYB22JSY-103)

摘　　要：目的观察槿柏洗剂治疗头皮脂溢性皮炎的临床疗效。方法将头皮脂溢性皮炎患者随机分为试验组和对照组,试验组使用自制槿柏洗剂治疗,对照组使用2%酮康唑洗剂治疗。观察2组治疗前及治疗2周、4周时的症状积分及临床疗效。结果 2组治疗2周、4周时红斑、脂溢、鳞屑、瘙痒及皮损面积症状评分均较治疗前明显改善(P均<0.05),且试验组改善情况明显优于对照组(P均<0.05);治疗2周、4周时试验组红斑、鳞屑、脂溢、瘙痒及皮损面积症状总有效率均显著高于对照组(P均<0.05);试验组综合疗效总有效率显著高于对照组(P<0.05)。2组均无严重不良反应发生。结论槿柏洗剂为外用治疗头皮脂溢性皮炎的有效中药制剂,且使用安全,值得研究应用。Objective It is to observe the clinical curative effect of homemade Jin Bai lotion （ JBL） in treatment of sebor-rheic dermatitis of scalp （ SDS） .Methods 210 patients with SDS by clinical diagnosis were selected and randomly divided into experimental group with 106 cases and control group with 104 cases.The patients were treated with JBL in the experimental group and 2%Ketoconazole Lotion in the control group.The symptom score before the treatment and after 2 weeks, 4 weeks of treatment were evaluated, and the clinical curative effect were observed.Results The symptom scores of erythema, scales, itching, seborrhea and skin lesions after treatment for 2 weeks and 4 weeks were markedly improved than before treatment in the both groups （ all P〈0.05） , and the improvement in the experimental group were significantly better than that in the con-trol group （all P〈0.05）.The total effective rates of symptom improvement for erythema, scales, itching, seborrhea and skin lesions after treatment for 2 weeks and 4 weeks in the experimental group were markedly higher than those in the control group （ all P〈0.05）.The comprehensive effect rate of the experimental group were significantly higher than that of the control group （P〈0.05）.There were no serious adverse reactions in the both groups.Conclusion JBL is a topical Chinese medicine preparation for treating SDS with higher effect and safety, so it is worthy of further clinical application.

关 键 词：槿柏洗剂 头皮脂溢性皮炎 酮康唑洗剂 

分 类 号：R758.732[医药卫生—皮肤病学与性病学]