注射用盐酸头孢甲肟与更昔洛韦的配伍稳定性考察  

Compatible Stability of Cefmenoxime for Injection with Ganciclovir for Injection

作　　者：王建欣[1] 黄志云[1] 郭俊利[1] 杨继章[1] 

机构地区：[1]河北医科大学第一医院,石家庄050031

出　　处：《中国药房》2015年第29期4066-4068,共3页China Pharmacy

基　　金：河北省医学科学研究重点课题(No.20120276)

摘　　要：目的:考察注射用盐酸头孢甲肟与注射用更昔洛韦在0.9%氯化钠注射液和5%葡萄糖注射液中的配伍稳定性。方法:在室温下观察注射用盐酸头孢甲肟与注射用更昔洛韦配伍后的外观及p H值变化,并采用高效液相色谱法测定两药的含量变化。结果:两药配伍后在6 h内外观及p H值均无明显变化,更昔洛韦含量均大于98%,但头孢甲肟含量下降至75.33%。结论:注射用盐酸头孢甲肟不能与注射用更昔洛韦在0.9%氯化钠注射液和5%葡萄糖中配伍使用。OBJECTIVE：To study the compatible stability of Cefmenoxime for injection with Ganciclovir for injection in0.9% Sodium chloride injection and 5% Glucose injection. METHODS：At room temperature,the appearance and p H of the mixtures were observed after Cefmenoxime for injection was compatible with Ganciclovir for injection. HPLC method was adopted to determine the content of them. RESULTS：No significant change was noted for the mixture in appearance and p H value. The content of ganciclovir was more than 98%,but that of cefmenoxime decreased to 75.33%. CONCLUSIONS：Cefmenoxime for injection can not be mixed with Ganciclovir for injection in 0.9% Sodium chloride injection and 5% Glucose injection.

关 键 词：头孢甲肟 更昔洛韦 高效液相色谱法 配伍 稳定性 

分 类 号：R978.1[医药卫生—药品] R969.1[医药卫生—药学]