缩宫素联合复方益母草口服液治疗人工流产术后出血的临床观察  

Clinical Observation of Oxytocin Combined with Compound Leonurus japonicus Oral Solution in the Treatment of Hemorrhage after Artificial Abortion

作　　者：钱坤[1] 张伟[1] 姜海英[2] 

机构地区：[1]唐山市妇幼保健院药剂科,河北唐山063000 [2]唐山市妇幼保健院妇产科,河北唐山063000

出　　处：《中国药房》2015年第29期4133-4135,共3页China Pharmacy

摘　　要：目的:观察缩宫素联合复方益母草口服液治疗人工流产术后出血的疗效、安全性及对正常月经恢复的影响。方法:选取人工流产患者100例,按随机数字表法分为治疗组和对照组,各50例。对照组患者在术后采用缩宫素肌内注射,10 U/次,q12 h,注射3次;治疗组患者在对照组的基础上加用复方益母草口服液,20 ml/次,3次/d,服用5 d。观察两组患者子宫出血持续时间、出血量、正常月经恢复时间及腹痛持续时间及不良反应。结果:治疗组患者子宫出血持续时间为(5.38±0.95)d,明显低于对照组的(8.58±1.32)d,差异有统计学意义(P<0.05);治疗组患者出血量少者(24例)高于对照组(9例),量多者(8例)低于对照组(24例),差异具有统计学意义(P<0.05);治疗组患者正常月经恢复时间为(27.34±3.87)d,显著短于对照组的(40.13±2.58)d,差异具有统计学意义(P<0.05);治疗组患者腹痛持续时间为(2.85±0.89)d,明显短于对照组的(5.02±1.33)d,差异有统计学意义(P<0.05)。两组患者均未见明显不良反应。结论:复方益母草口服液治疗人工流产术后出血疗效显著,可明显缩短术后子宫出血时间,减少出血量,较早恢复正常月经时间,改善人工流产术后腹痛症状,服用方便且安全性较好。OBJECTIVE：To observe therapeutic efficacy of Compound Leonurus japonicus oral solution in the treatment of hemorrhage after artificial abortion and its effect and safety on normal menstruation recovery. METHODS：100 cases of artificial abortion selected and randomly divided into treatment group and control group,with 50 cases in each group. Control group received oxytocin intramuscularly after surgery,10 U/time,12 h/time,for 3 times;treatment group was additionally given Compound L. japonicus oral solution,2 piece/time,3 times/d,for 5 days,on the basis of control group. Metrorrhagia duration,hemorrhage amount,normal menstruation recovery and duration of abdominal pain and ADR were all observed in 2 groups. RESULTS：The metrorrhagia duration [（5.38±0.95）d] of treatment group was significantly lower than that [（8.58±1.32）d] of control group,with statistical significance（P〈0.05）;hypomenorrhea cases（24 cases）of treatment group was higher than those（9 cases）of control group;menorrhagia cases（8 cases）was lower than those（24 cases）of control group;with statistical significance（P〈0.05）.The normal menstruation recovery time [（27.34±3.87）d] of treatment group was significantly shorter than that [（40.13±2.58）d] of control group,with statistical significance（P〈0.05）;the duration of abdominal pain [（2.85±0.89）d] in treatment group was significantly shorter than [（5.02 ± 1.33）d] in control group,with statistical significance（P〈0.05）.Obvious ADR was not found in both groups. CONCLUSIONS：Compound L. japonicus oral solution is effective in the treatment of hemorrhage after artificial abortion,can significantl shorten metrorrhagia duration and hemorrhage amount,recover normal menstruation early,improve the symptoms of abdominal pain after operation and is easy to take and good safety.

关 键 词：复方益母草口服液 人工流产 缩宫素 子宫出血 

分 类 号：R714.21[医药卫生—妇产科学]