皮肤科住院患者血清铁蛋白及鳞状上皮细胞癌抗原的检测  

Detection of Serum Ferritin and Squamous Cell Carcinoma Antigen in Hospitalized Patients

作　　者：马毳毳[1] 刘艳[1] 尹佳锋 杨生莲[1] 赵波[1] 

机构地区：[1]西安交通大学医学院第二附属医院皮肤科,陕西西安710004

出　　处：《中国皮肤性病学杂志》2015年第10期1023-1025,1028,共4页The Chinese Journal of Dermatovenereology

基　　金：西安交大院科技骨干项目(RC(GG)201204);多发性家族性毛发上皮瘤基因突变及临床研究

摘　　要：目的观察皮肤科住院患者血清铁蛋白(FET)、血清鳞状上皮细胞癌抗原(SCCA)水平变化情况及其意义。方法对入选的514例皮肤科住院患者进行血清FET和SCCA检测,并随机选取同期其它科室住院患者514例作为对照组,比较两组患者血清FET和SCCA值。结果皮肤科住院患者组血清FET升高129例(25.10%),SCCA升高257例(50.00%),对照组患者血清FET升高6例(1.17%),SCCA升高8例(1.56%)。FET检测结果:红斑狼疮(4/7)、多形红斑(3/6)、皮肌炎(19/40)、荨麻疹(11/25)、带状疱疹(27/95)、硬皮病(3/14)等的血清FET值有所升高。SCCA检测结果:银屑病(92/96)、湿疹(21/22)、红皮病(24/26)、泛发性神经性皮炎(6/7)、嗜酸性粒细胞增多性皮病(7/9)、毛发红糠疹(3/4)等的血清SCCA值升高明显。皮肤肿瘤患者血清FET值正常,血清SCCA值升高(3/6)。结论结缔组织病类疾病、多形红斑、荨麻疹、带状疱疹可出现血清FET值升高。鳞状上皮增生明显、伴有大量鳞屑的皮肤病血清SCCA值可能升高。血清FET和SCCA值不是常见皮肤肿瘤(除皮肤鳞癌)的特异性指标。Objective To examine the serum FET and SCCA levels of patients with skin diseases and their clinical significance. Methods The serum FET and SCCA levels of 514 cases of hospitalized patients in our department and 514 cases of eligible patients of other departments were detected and analyzed. Results The number and percentage of patients with skin diseases who had higher serum FET and SCCA levels were 129 （25.10%） and 257 （50. 00% ）, respectively, significantly higher than those of the control group. The serum FET levels of connective tissue disorders also increased . The serum SCCA levels of psoriasis （92/96） , eczema （21/22）, erythrodermia（ 24/26）, generalized neurodermatitis （6/7）, hypereosinophilic dermatopathy （7/9）, pityriasis rubra pilaris （3/4） increased significantly. The serum FET and SCCA levels of skin cancer had no obvious change. Conclusion The serum FET levels of connective tissue disorders might rise. Squa- mous cell hyperplasia accompanied by a large scaly skin disease had higher serum SCCA level, especially in the erythroderma, psoriasis, hypereosinophilic dermatopathy, and dermatitis. The higher serum FET and SCCA levels were not a common skin cancer specific indicator （except for SCC）.

关 键 词：铁蛋白 鳞状上皮细胞癌抗原 结缔组织病 皮肌炎 银屑病 红皮病 

分 类 号：R751[医药卫生—皮肤病学与性病学]