深在性红斑狼疮1例  

A Case of Lupus Erythematosus Profundus

作　　者：温斯健[1] 胡彬[1] 宋昊[1] 孙建方[1] 

机构地区：[1]中国医学科学院北京协和医学院皮肤病研究所,江苏南京210042

出　　处：《中国皮肤性病学杂志》2015年第10期1066-1067,共2页The Chinese Journal of Dermatovenereology

摘　　要：患者女,30岁。右下颌、左上臂斑块伴关节痛3年。皮肤科情况:右下颌及左上臂伸侧见四处大小不一的类圆形暗红色斑块,边清,触之质硬,中央萎缩凹陷,表面无破溃。皮损组织病理检查示:表皮变薄,基底液化,真皮内灶状淋巴细胞浸润,皮下脂肪小叶内淋巴、组织细胞浸润,有少许多核巨细胞。直接免疫荧光(LBT):表皮基底膜带见Ig G和C3呈线状沉积。诊断:深在性红斑狼疮。治疗:每天予泼尼松20mg、羟氯喹0.2g(2次/d)口服治疗,皮损渐好转,现随访中。A 30-year-old female patient presented with a 3 years history of plaques on the right lower jaw and left upper arm accompanied with join pain. Physical examination found that four dark red plaques of various sizes located on the right lower jaw and the left upper arm. Histopathological examination showed epidermal atrophy, liquefaction degeneration of basal cells, focal lymphocyte infiltration in the dermis, lymphocyte, histocyte and a few multinuclear giant cells infiltration in the subcutaneous fat. Direct immunofluorescence （LBT） showed continuous linear deposits of C3 and IgG in the basement membrane zone. Thus, a diagnosis of lupus erythematosus profundus was confirmed. After taking prednisone （oral 20 mg, once a day） and hydroxychloroquine sulfate （oral 0.2g, twice a day） the skin lesions became soft and smaller.

关 键 词：红斑狼疮 深在性 泼尼松 羟氯喹 

分 类 号：R758.62[医药卫生—皮肤病学与性病学]