碱性成纤维细胞生长因子联合修护霜对激光治疗痤疮瘢痕术后创面愈合的影响  

Clinical Effectiveness of the United Application with rb FGF and ACRSC on Postoperative Wound-healing in Treatment of Acne Scar Using Fractional Erbium Laser MCL30

作　　者：李敏[1] 李雪莉[1] 李旭阳[2] 张守民[1] 禹卉千[1] 邓丽娜[1] 李丽娜[1] 郑颖娜[1] 尹光文[2] 李振鲁[1] 

机构地区：[1]河南省人民医院皮肤科,河南郑州450003 [2]郑州大学第一附属医院皮肤科,河南郑州450052

出　　处：《中国皮肤性病学杂志》2015年第10期1100-1102,共3页The Chinese Journal of Dermatovenereology

基　　金：河南省重点科技攻关项目(122102310539)

摘　　要：目的探讨碱性成纤维细胞生长因子(rb FGF)联合雅漾活泉修护霜(ACRSC)对点阵激光治疗痤疮瘢痕术后创面的影响。方法 66例痤疮瘢痕患者分为对照组(A组)、ACRSC组(B组)和rb FGF与ACRSC联合治疗组(C组),均采用MCL30铒点阵激光(德国阿司克莱)治疗,创面皮肤出现少量渗血、渗液即终止,共治疗3次,间隔时间为2个月。术后所有患者均使用雅漾活泉喷雾冷敷创面,3次/d,每次20min。对照组于点阵激光治疗后未再使用药物;ACRSC组术后第3天起在皮损处外用使用ACRSC,1次/d,共1个月。联合治疗组于点阵激光治疗后4h后皮损部位使用rb FGF,3次/d至痂皮完全脱落,术后第3天开始在皮损处外用ACRSC,1次/d,共1个月。随访由两位主治医师接诊,分别于激光术后第3,7,14,30,60天评估患者的红肿时间、渗出时间、脱痂时间、红斑持续时间和患者的满意度,结合患者术前术后照片及临床问卷调查资料共同判定疗效。结果所有受试者未见色素减退、感染及瘢痕增生等不良反应。ACRSC组红肿、渗出时间与对照组相比较[(2.96±1.34)d vs(3.26±1.43)d,(2.09±0.59)d vs(2.45±0.65)d]差异无统计学意义(均P﹥0.05),联合治疗组与对照组相比较[(2.72±1.31)d vs(3.26±1.43)d,(1.99±0.63)d vs(2.45±0.65)d]比较差异有统计学意义(均P﹤0.05);3组在脱痂时间和红斑持续时间上两两相比差异均具有统计学意义(P﹤0.05)。结论 rb FGF联合ACRSC能够加速点阵激光术后创面的愈合,减少红斑及色素沉着等不良反应的发生。Objective To study effectiveness of the united application of rbFGF and ACRSC on postoperative wound - healing in treatment of ache scar using fractional Erbium laser MCL30. Methods Sixty-six patients with ache scar were divided into control group （group A, 12 cases） ,ACRSC group （group B,27 cases） and united treatment group （group C ,27 cases） . All patients were treated 3 times with interval 2 months using fractional Erbium laser MCL30 and terminated whose skin was appearing little amount of bleeding or drainage. Postoperative wound-cooling with avene cicalfate spray was applied by 3 times a day, 20 minutes each time. Group A was only treated by fractional Erbium laser MCL30 with no drugs; group B was done with ACRSC （1 time per day） from postoperative 3rd day（ 1 month in total） ;and group C was applicated jointly with rbFGF （ 3 times a day）from postoperative 4th hour and with ACRSC （1 time per day） from postoperative 3 rd day （ 1 month in total） . The results of effect and follow-up including seepage time, callus time , duration of erythema and patients＇ satisfaction in postoperative 3rd,7th, 14th,30th and 60th day were assessed by two doctors. Results There were no pigment loss,infection , scar hyperplasia, and other adverse reactions in the whole groups. There were no obviously statistical significance in redness, seepage time between B and Agroups [ （ 2.96 ± 1.34） d vs （ 3.26 ± 1.43 ） d, （2. 09 ± 0. 59 ） d vs （2.45 ±0. 65 ） d） ] （ P 〉 0.05 ）, while there were obvious differences compared group C with group A [ （2. 72 ± 1.31 ） d vs （ 3.26 ±1.43 ） d, （ 1.99 ±0. 63）d vs（ 2. 45 ±0. 65）d） ] （P 〈 0. 05）. Compared by debridement and erythema,three groups have obvious differences （P 〈 0. 05 ）. Conclusion It is a kind of feasible, safe, effective method on accelerating postoperative wound-healing with few side-effects , and has good cosmetic effect.

关 键 词：激光治疗 瘢痕 成纤维细胞生长因子 治疗结果 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]