67例儿童血清维生素A、D、E水平研究  

Study on the levels of serum vitamin A,D,E in 67 children

作　　者：李娜[1] 王建红[1] 金春华[1] 张悦[1] 张丽丽[1] 王晓燕[1] 王贺茹[1] 宋文红[1] 高海涛[1] 倪君君 

机构地区：[1]首都儿科研究所儿童保健科,北京100020 [2]北京国立柏林医学科技发展有限公司,北京100020

出　　处：《中国儿童保健杂志》2015年第10期1093-1096,共4页Chinese Journal of Child Health Care

基　　金：国家科技支撑项目;第三方医学检验服务支撑平台(2012BAH24F04)

摘　　要：目的了解婴幼儿血清维生素A、D、E水平状况，为临床诊治工作提供参考。方法以2013年1—3月在首都儿科研究所附属儿童医院保健门诊67名要求健康体检儿童作为研究对象，采用高效液相色谱检测血清维生素A、25羟维生素D[25（0H）D]、维生素E水平，收集其基本情况、喂养方式、体格等方面信息。结果67名儿童中，男40例，女27例。维生素A水平为（0．23±0．07）mg／L，缺乏率34．3％，不同月龄段血清水平差异有统计学意义（F=5．866，P=0．001），随月龄增加血清维生素A缺乏率逐渐减少，O～4个月组最低[（O．17±0．04）mg／L]，缺乏率高达68．8％；不同喂养方式血清维生素A水平差异有统计学意义（F=2．838，P=0．045），纯母乳喂养组血清水平偏低[（O．18±0．03）mg／L]，缺乏率为60．0％。血清25（0H）D水平为（102．26土90．54）nmol／L，缺乏率为13．3％；不同喂养方式水平差异有统计学意义（F=2．95l，P=0．038），纯母乳喂养婴儿仍偏低[（96．93±20．42）nmol／L]，缺乏率较高为33．3％。血清维生素E水平为（10．09土2．76）mg／L，不足率仅为13．4％，未发现缺乏儿童，维生素E营养状况良好。结论婴幼儿维生素A、D营养状况不容乐观，应针对高危人群及时施加干预以预防维生素缺乏症的发生。Objective To identify the status of serum vitamin A,D,E levels of infants and young children and to pro- vide reference for clinical diagnosis and treatment. Methods Totally 67 healthy infants and young children were recruited for the study from January to March in 2013. Serum vitamin A, 25-hydroxy vitamin D[25 （OH）D], vitamin E were deter- mined. Basic situation,feeding methods,physical and other aspects of the information were collected. Results Altogether 67 children,included 40 boys and 27 girls. The mean serum vitamin A was （0. 23±0. 07） mg/L, the rate of lack was 34.33 %. Stratified analysis showed serum levels of different age had differences （F= 5. 866, P= 0. 001）. Serum vitamin A deficiency rate gradually decreased with the month age increase. The 0～4 months of age group was the lowest with （0.17 4±0.04） mg/L,the lack rate was high as 68. 750% There were also differences in serum vitamin levels of different feeding methods （F= 2. 838 ,P=0. 045）, serum levels of exclusively breastfed infants was minimum with （0.18 ±0.03） rag/L, the lack rate was 60.00%. Serum 25（OH）D level was （102.26±90.54） nmol/L,the lack rate was 13.33%. There were differ- ences between the different feeding methods （F=2. 951 ,P= 0. 038）. Serum levels of exclusively breastfed infants was low with （96.93±20.42） nmol/L,the higher rate of lack was 33.34‰. Serum vitamin E level was （10.09±.276） mg/L,rate of insufficient was only 13.4%, and there were no children. Vitamin E was better overall nutritional status. Conclusions Children＇s nutrition of vitamin A and 25（OH）D situations were not optimistic. The attention of the government should be improved to timely applying intervention to prevent vitamin deficiency for high-risk groups.

关 键 词：维生素A 25羟维生素D 维生素E 血清水平 

分 类 号：R179[医药卫生—妇幼卫生保健]