血清PCT和IL-6对重症急性胰腺炎继发感染的诊断价值  

Values of serum PCT and IL-6 for diagnosis of infection secondary to severe acute pancreatitis

作　　者：张志成[1] 廖玲[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所检验科,重庆400042

出　　处：《检验医学与临床》2015年第19期2895-2896,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨降钙素原(PCT)和白细胞介素6(IL-6)对重症急性胰腺炎(SAP)继发感染的诊断价值。方法收集130例SAP患者作为研究对象,按照是否发生继发感染分为继发感染组和非继发感染组,比较两组的PCT和IL-6水平,采用ROC曲线分析PCT和IL-6对SAP继发感染的诊断效能。结果继发感染组PCT和IL-6水平均高于非继发感染组,差异均有统计学意义(P<0.01)。PCT和IL-6的ROC曲线下面积(AUC)分别为0.843和0.708。PCT的特异性为88.4%,敏感性为55.2%,IL-6的特异性为81.6%,敏感性为51.9%。结论 PCT和IL-6可作为判断SAP继发感染的指标,较IL-6而言,PCT的对SAP继发感染的鉴别能力更强。Objective To investigate the value of PCT and IL‐6 in the diagnosis of secondary infection in se‐vere acute pancreatitis（SAP） .Methods 130 cases of SAP in our hospital were collected as the research subjects and divided into the secondary infection group and the non‐secondary infection group according to whether secondary in‐fection occurring .The PCT and IL‐6 levels were compared between the two groups .The receiver operating character‐istic（ ROC） curve was adopted to analyze the efficiency of PCT and IL‐6 in diagnosing secondary infection .Results The levels of IL‐6 and PCT in the secondary infection group were higher than those in the non‐secondary infection group ,and the difference was statistically significant （P〈 0 .01） .The area under the curve（AUC） of PCT and IL‐6 was 0 .843 and 0 .708 respectively .The specificity and sensitivity of PCT were 88 .4% and 55 .2% respective ,which of IL‐6 were 81 .6% and 51 .9% respectively .Conclusion PCT and IL‐6 can be used as the indicators for the diagno‐sis of secondary infection of SAP ,compared with PCT ,IL‐6 has a stronger ability to identify the secondary infec‐tion .

关 键 词：降钙素原 白细胞介素 6 急性胰腺炎 继发感染 

分 类 号：R657.51[医药卫生—外科学]