肥胖及腹型肥胖人群的血清游离脂肪酸水平与胰岛素抵抗的关系研究  

Study on relation between free fatty acids levels with insulin resistance in obesity and abdominal obesity populations

作　　者：陈效琴[1] 俞安清[1] 张博林[1] 赵诤[1] 蹇国 何平[1] 伏攀[1] 任静[1] 

机构地区：[1]四川省广元市中心医院检验科,628000

出　　处：《检验医学与临床》2015年第19期2917-2918,2921,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨肥胖及腹型肥胖人群的游离脂肪酸(FFA)水平及糖脂代谢情况,研究肥胖患者FFA与胰岛素抵抗(IR)状态形成的关系。方法按体质量指数(BMI)将560例患者分为肥胖组(BMI≥25kg/m2)及BMI正常对照组(18kg/m2≤BMI<25kg/m2),并通过腰围(WC)将BMI正常对照组分为BMI正常非腹型肥胖组和BMI正常腹型肥胖(男WC≥85cm;女WC≥80cm)两个亚组,测量各组身高、体质量、腰围,计算BMI;同时测定血清FFA、脂蛋白(a)[LP(a)]、胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、同型半胱氨酸(HCY)、血糖(GLU)、C肽(CP)、胰岛素(INS)等指标。将各组指标进行比较及相关性分析。结果肥胖组血清FFA水平明显高于BMI正常对照组(P<0.01);BMI正常非腹型肥胖组血清FFA水平明显高于BMI正常腹型肥胖组(P<0.01);采用Spearman相关分析显示,正常对照组的血清FFA水平与LP(a)、INS呈正相关,BMI正常的腹型肥胖组血清FFA水平与BMI、LP(a)、TG、CP、INS呈正相关,肥胖组的血清FFA水平与BMI、LP(a)、TG、LDL-C、CP、INS呈正相关。结论血清FFA是肥胖及腹型肥胖患者体内参与IR的重要环节及因素。Objective To investigate the levels free fatty acids（FFA ） levels and the glucolipid metabolism sit‐uation in obesity and abdominal obesity populations and to research the relationship of FFA with insulin resistance （IR） .Methods According to body mass index（BMI） 560 cases of obesity s were divided into the obese group（BMI ≥25 kg/m2 ） and BMI normal control group（18 kg /m2 ≤ BMI 〈 25 kg/m2 ） ,and according to the waist circumference （WC） the BMI normal control group was re‐divided into the two subgroups of non‐abdominal obesity group and BMI normal abdominal obesity group（male ：WC ≥ 85 cm ;female ：WC ≥ 80 cm ） .The height ,body weight and WC were measured in various groups .BMI was calculated ;at the same time serum FFA ,blood liapid[LP（a）] ,TC ,TG ,LDL‐C , HDL‐C ,homocysteine（HCY ） ,glucose（GLU ） and C‐peptide（CP） and insulin（INS） were detected .The indicators were compared among groups and the correlation analysis was performed .Results Serum FFA level in the obese group was significantly higher than that in the BMI normal control group（P〈 0 .01） ;serum FFA level in the normal BMI and non‐abdominal obesity group was significantly higher than that in the normal BMI and abdominal obesity group（P〈 0 .01） .The Spearman correlation analysis showed that serum FFA level in the control group was positively correlated with LP（a） and INS ,the serum FFA level in the normal BMI and abdominal obesity group was positively correlated with BMI ,LP（a） ,TG ,CP and INS ,the serum FFA leveling the obese group was positively correlated with BMI ,LP（a） ,TG ,LDL‐C ,CP and INS .Conclusion Serum FFA is an important link and factor participating in insulin resistance in obese and abdominal obesity patients .

关 键 词：肥胖 游离脂肪酸 糖脂代谢异常 

分 类 号：R259.422.2[医药卫生—中西医结合]