尿α1-微球蛋白筛查意义及其危险因素分析  

Significance of Early Screening Urinary α1- MG and the Risk Fators of It

作　　者：李燕燕[1] 马清[1] 

机构地区：[1]首都医科大学附属北京友谊医院医疗保健中心内科,100050

出　　处：《医学研究杂志》2015年第9期85-87,共3页Journal of Medical Research

摘　　要：目的尿α1-MG作为早期肾损害标志物,对其进行筛查可早期发现慢性肾脏病,通过对肾功能在CKD G3期以上尿α1-MG进行分析,为早期筛查CKD提供理论依据。方法对982例健康体检尿常规蛋白为阴性的人群,对其尿α1-MG进行统计学分析。结果尿α1-MG的阳性率为25.3%,阳性与高血压、糖尿病、冠心病、糖化血红蛋白水平、空腹血糖水平、高甘油三脂、低高密度脂蛋白胆固醇、吸烟、饮酒有关,其中高血压、空腹血糖、吸烟是其独立危险因素。结论在尿蛋白为阴性的情况下,对高危人群需行尿α1-MG检查是十分必要的。Objective To provide the theory basis for CKD diagnosis, through the study of the samples＇ urinaryα1- MG whose classification of renal function is between CKD G1.3. Methods Totally 982 samples were took into account whose PRO were negative. The α1- MG were statistical analysed. Results The positive rate of urinary α1- MG was 25.3%. It was followed with hypertension, diabetes,coronary heart disease, glycosylated hemoglobin, fasting blood - glucose, high triglycerides, low HDL cholesterol, smoking and drinking. Hypertension and smoking were the independent risk factors. Conclusion It is very necessary to test urinary α1- MG for high - risk grous, in the case of urinary protein were negative.

关 键 词：慢性肾脏病 肾小管间质损害 尿Α1-MG 肾功能进展 

分 类 号：R446[医药卫生—诊断学] R692[医药卫生—临床医学]