羟氯喹对类风湿关节炎患者关节滑液IL-1α和IL-6表达影响的研究  

Level of IL- 1α and IL- 6 in Joint Synovial of Rheumatoid Arthritis by Treatment with Hydroxychloroquine

作　　者：张舸[1,2] 杨群智 付爽[1,2] 费雅楠[1,2] 

机构地区：[1]北京市海淀医院 [2]北京大学第三医院海淀院区风湿免疫科,100080

出　　处：《医学研究杂志》2015年第9期100-102,共3页Journal of Medical Research

基　　金：国家自然科学基金资助项目(81273309)

摘　　要：目的探讨羟氯喹对类风湿关节炎患者关节滑液中IL-1α和IL-6的影响。方法选取类风湿关节炎患者60例,分为A组羟氯喹治疗组,B组甲氨蝶呤治疗组,C组甲氨蝶呤和羟氯喹联合治疗组,追踪随访1年,观察药物疗效、不良反应以及比较用药前后,类风湿患者关节滑液中IL-1α和IL-6水平的变化。结果经治疗后C组的有效率明显高A组B组;A组与B组相比较,两组的疗效比较差异无统计学意义;A组治疗的不良反应最少;治疗后,关节滑液检测IL-1α和IL-6的水平降低,且A组降低的水平与B组接近。结论证实单独使用羟氯喹对类风湿关节炎的抗炎效果明显,且甲氨蝶呤与羟氯喹合用的作用更强,从治疗的角度考虑,羟氯喹的不良反应小,更适合于临床需长期治疗的类风湿关节炎患者。Objective To investigate the level of IL - 1α and IL - 6 in the synovial of joint treated with hydroxychloroquine. Methods Sixty patients were acted as three groups： those in A group were treated with hydroxychloroquine, in B group were treated with methotrexate and in C group were treated with hydroxychloroquine couples with methotrexate. The clinical symptoms and side effects of these treatments were evaluated for 1 year. The level of IL -1α and IL - 6 were further detected. Results After these treatments, the effective power was best in C group compared with A group and B group, and there was no significant difference between A group and B group. The side effect was least in A group. The level of IL - 1α and IL -6 in synovial of joint was obviously decreased in A group. Conclusion Hydroxychloroquine was a good choice to rheumatoid arthritis, especially to the long - turm use,which has obvious anti - inflammation ac- tiion and small side effects.

关 键 词：类风湿关节炎 甲氨蝶呤 羟氯喹 IL-1Α IL-6 

分 类 号：R593.22[医药卫生—内科学]