男性染色体多态对IVF/ICSI-ET结局的影响  

The Effect of Male chromosomal polymorphism on IVF/ICSI-ET outcomes

作　　者：郭威 郭艺红[2] 苏迎春[2] 杨庆岭[2] 辛志敏[2] 

机构地区：[1]河南省驻马店市中心医院,463000 [2]郑州大学第一附属医院生殖医学中心

出　　处：《中国计划生育学杂志》2015年第10期670-673,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨接受体外受精/卵胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)助孕中男性染色体多态性对助孕结局的影响。方法:采用回顾性研究方法,比较男方染色体多态、女方染色体正常的不孕夫妇(染色体多态组132对)与无染色体核型异常的不孕夫妇(染色体正常组3386对)IVF/ICSI-ET助孕结局。结果:接受IVF-ET助孕者中,男性染色体多态组与染色体正常组的受精率(65.5%,67.9%)、卵裂率(98.7%,9.4%)、种植率(35.3%,34.5%)、临床妊娠率(55.1%,53.5%)、早产率(9.8%,8.9%)等指标的差异均无统计学意义(P>0.05)。接受ICSI-ET助孕者中,男性染色体多态组多原核受精率高于染色体正常组,差异有统计学意义(72.7%,70.1%)(P<0.05),其他结局包括卵裂率(97.4%,97.8%)、优质胚胎率(74.6%,77.2%)、种植率(35.4%,38.1%)、临床妊娠率(58.1%,58.6%)、早产率(8.3%,7.2)等指标的差异均无统计学意义(P>0.05)。结论:男性染色体多态性可能导致ICSI-ET中多原核受精率上升,但对IVF/ICSI-ET结局均无明显影响。Objective： To explore the effect of male chromosome polymorphism on ART. Methods： 3518 infertile cou- ples asked for ART treatment for the first time were recruited in this study. The patients were divided into two groups according to the karyotype： the research group, 132 couples with chromosome polymorphism from male; the control group, 3386 couples with normal karyotype. Results： There were no statistically significant difference in the cleavage rate（65.5% VS. 67.9%）, high quality embryo rate（98.7% VS. 9.4%）, implantation rate（35.3% VS. 34.5%）, pregnancy rate（55. 1% VS. 53. 5 %） and early miscarriage rate（9. 8% VS. 8.9%） between the two groups （P〉0.05）. But there was a higher polypronuclear rate in research group compared with control group among the patients undergo- ing ICSI-ET treatment （P〈0.05）. Conclusion： Chromosome polymorphism from male may increase polypronuclear rate, but appears to have no adverse effects on the other outcomes of IVF/ICSI-ET, such as cleavage rate,implantation rate, clinical pregnancy rate and abortion rate.

关 键 词：染色体多态 体外受精 多原核受精 辅助生殖技术 

分 类 号：R714.8[医药卫生—妇产科学]