补佳乐联合黄体酮防治稽留流产患者清宫术后宫腔粘连的临床疗效  

The clinical effect of progynova combined with progesterone to prevent intrauterine adhesion of patients with missed abortion after uterine curettage

作　　者：江慧英[1] 

机构地区：[1]浙江省泰顺县人民医院妇产科,325500

出　　处：《中国计划生育学杂志》2015年第10期674-676,680,共4页Chinese Journal of Family Planning

摘　　要：目的：探讨补佳乐联合黄体酮防治稽留流产患者清宫术后宫腔粘连的临床疗效。方法：选取2010年8月~2014年8月本院诊治的稽留流产后行清宫术患者103例,其中观察组52例,对照组51例。对照组行清宫术后不给予药物治疗,观察组在清宫术后第5天口服补佳乐（2mg/次,1次/d）及黄体酮胶囊（50mg/次,1次/d）进行治疗,连续用药3周。观察两组术后出血时间、出血量、腹痛持续时间及程度、月经量变化及宫腔粘连等情况。结果：与对照组比较,观察组在出血量、出血时间、腹痛持续时间方面明显降低（t=4.615、5.037、10.620,P〈0.01）;以轻度腹痛为主,两组间疼痛程度比较差异具有统计学意义（χ2=7.890,P〈0.05）;月经减少及闭经比例明显降低（χ2=6.272,P〈0.05）,且患者月经复潮时间缩短（t=6.537,P〈0.01）,而宫腔粘连发生率明显低于对照组（χ2=4.039,P〈0.05）。结论：采用黄体酮联合补佳乐治疗可以有效预防稽留流产清宫术后宫腔粘连,提高患者术后生活质量,值得在临床推广。Objective： To analyze the effect of progynova combined with progesterone to prevent intrauterine adhesions of patients with missed abortion after uterine curettage. Method：One hundred and four patients with missed abortion were recruited and divided into the observation group （52 cases） and the control group （ 51 cases）. Patients in control group were not given any medication after uterine curettage, while patients in observation group took progynova （2 mg, once a day） for 5 days and progesterone capsules （50 mg, once a day） for 3 weeks after curettage. The bleeding duration and bleed volume, the duration and the degree of abdominal pain, the change of menstrual and the rate of in- trauterine adhesion were observed in both groups. Result： Compare to control group, bleeding volume, duration of bleeding or abdominal pain was significant lower （t=4.615, 5.037, 10.620, P〈0.01）. In observation group, most of the patients were mild abdominal pain, and the degree of pain was significant lower （χ 2 = 7.890, P 〈0.05）. The rate of hypomenorrhea and amenorrhea was also lower in observation group significantly （χ2= 6.272, P〈0.05） and the time of menses recovery was shorter （t= 6.537, P〈0.01）. The incidence of intrauterine adhesions was significantly lower （χ2=4.039, P〈0.05）. Conclusion： Using progesterone combined with progynova can effectively prevent intrauterine adhesions in patients with missed abortion after uterine curettage.

关 键 词：补佳乐 黄体酮 稽留流产 清宫术 宫腔粘连 

分 类 号：R713[医药卫生—妇产科学]