5437例男性不育患者的染色体核型分析  

Analysis of chromosome karyotypes in 5437 male infertile patients

作　　者：张佳仕 刘红杰 林奇 沈树秋 黄丽施 尹彪 曾勇 

机构地区：[1]深圳中山泌尿外科医院生殖医学中心,深圳中山生殖与遗传研究所,518045

出　　处：《中国计划生育学杂志》2015年第10期681-683,687,共4页Chinese Journal of Family Planning

基　　金：深圳市科技研发资金项目(JCYJ20130401092000370);深圳市基础研究项目(JCYJ20140415114532535)

摘　　要：目的：探讨男性不育与染色体核型的关系。方法：对2011年9月~2013年10月来本院检查的5437例男性不育患者进行精液常规检查及染色体核型分析。根据精液参数进行分组,综合分析各组染色体核型及其特点。结果：染色体畸变率无精子症组（8.33%）及少弱畸形精子症组（2.84%）,均高于精液正常组（1.02%）,差异有统计学意义（P〈0.01）;染色体多态性的发生率3组无统计学差异（P〉0.05）。结论：染色体异常是导致男性不育的重要原因之一;染色体多态性一般不会造成生精障碍;男性不育患者有必要进行染色体核型分析。Objective： To explore the relationship between chromosome karyotyping and male infertility. Method： Chromosome karyotyping and semen analysis were carried out in 5437 infertile men from September 2011 to October 2013 at Shenzhen zhongshan urology hospital. The patients were assigned to three groups according to their semen pa- rameters. Chromosome karyotyping was performed for all patients in three groups. Results： The chromosome abnor- mality rate of patients in azoospermia group was 8.33%, which was significantly higher than that of in normal semen parameters group（1.02%）. The chromosome abnormality rate of patients in oligo- or astheno- or teratozoospermia group was 2.84%, which was also higher than that of in normal semen parameters group. The incidence of chromo- somal polymorphisms did not significantly differ in patients among the three groups. Conclusion： Chromosomal abnor- mality is one of the important causes of male infertility, while chromosome polymorphism does not cause spermatogen- esis failure. Chromosome Karyotyping should be carried out in all patients with male infertility.

关 键 词：染色体核型分析 男性不育 精液 遗传咨询 

分 类 号：R698.2[医药卫生—泌尿科学]