辛伐他汀联合依折麦布对冠心病患者的作用机制研究  

Mechanism study of simvastatin combined with ezetimibe in treatment of coronary heart disease

作　　者：黄珊[1] 李天发[1] 李巍景[1] 孔月琼[1] 林云[1] 

机构地区：[1]海南医学院附属医院心内科,海口570102

出　　处：《中国临床药理学杂志》2015年第19期1901-1903,共3页The Chinese Journal of Clinical Pharmacology

基　　金：海南医学院科研培育基金资助项目(HY2012-001)

摘　　要：目的探讨辛伐他汀联合依折麦布对冠心病患者血浆microRNA155和血清肿瘤坏死因子-α(TNF-α)、C反应蛋白水平的影响。方法 95例患者随机分为试验组49例和对照组46例。2组患者均给予常规对症基础治疗。试验组给予辛伐他汀20 mg,依折麦布10 mg,每天1次,每晚服用;对照组给予依折麦布治疗,用法用量同试验组。2组疗程均为12周。比较2组治疗前后血浆microRNA155和血清TNF-α、C反应蛋白及低密度脂蛋白胆固醇(LDL-C)和总胆固醇(TC)水平变化。结果治疗后,2组microRNA155、TNF-α、C反应蛋白均较治疗前显著降低(P<0.05),试验组显著低于对照组(P<0.05)。2组LDL-C、TC治疗后较治疗前显著降低(P<0.05),试验组LDL-C、TC治疗后显著低于对照组(P<0.05)。2组患者治疗期间均未发生明显不良反应。结论辛伐他汀联合依折麦布对冠心病患者的作用机制可能与降低血浆microRNA155和血清TNF-α、C反应蛋白水平有关。Objective To investigate the impact of simvastatin and ezetimibe on the changes of plasma microRNA155 and TNF- α,C- reactive protein level of patients with coronary heart disease.Methods Ninety- five patients were randomly divided into treatment group（ n = 49） and control group（ n = 46）. Patients in two groups were given conventional treatment. Patients in treatment group were given simvastatin 20 mg,and ezetimibe 10 mg,qn,patients in control group only given ezetimibe. Two groups were treated for 12 weeks. The levels of plasma microRNA155 and serum tumor necrosis factor- α（ TNF- α）,C reactive protein,low density lipoprotein cholesterol（ LDL- C） and cholesterol（ TC） before and after treatment were compared between two groups. Result The levels of microRNA155,TNF- α,C reactive protein after treatment of the two groups were significantly lower than those before treatment（ P〈0. 05）,and treatment group were lower than control group（ P〈0. 05）. The LDL- C and TC after treatment of the two groups were significantly lower than before treatment（ P〈0. 05）,and treatment group were significantly lower than control group（ P〈0. 05）. No obvious adverse reaction was observed in two groups.Conclusion The mechanism of simvastatin and ezetimibe in treatment ofcoronary heart disease may be related to the decreased levels of plasma microRNA155 and serum TNF- α and C reactive protein.

关 键 词：冠心病 辛伐他汀 依折麦布 microRNA155 肿瘤坏死因子-Α C反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病] R972.6[医药卫生—内科学]