手术治疗结直肠癌对于CD133分子表达的影响与临床意义  

Effect of surgical treatment of colorectal cancer on CD133 molecule expression and its clinical significance

作　　者：李伟林[1,2] 李彩丽[3] 

机构地区：[1]南方医科大学附属南方医院普外科,广州510515 [2]深圳市中医院普外科,广东深圳518033 [3]湖北医药学院附属人民医院消化内科,湖北十堰442000

出　　处：《中国临床药理学杂志》2015年第19期1925-1927,共3页The Chinese Journal of Clinical Pharmacology

基　　金：湖北省教育厅课题基金资助项目(B20122425)

摘　　要：目的探讨手术治疗结直肠癌对CD133分子表达的影响与临床意义。方法将120例结直肠癌患者随机分为试验组60例与对照组60例。试验组予以腹腔镜下手术切除治疗,对照组予以传统开腹手术治疗。2组患者术后均给予静脉注射72-162 mg·m-2奥利沙铂,第1天＋静脉滴注200 mg·m-2亚叶酸钙,第1天＋静脉注射1.30 g·m-25-氟尿嘧啶,第1,2天。2组患者1个周期均为21 d,共治疗3个周期。比较2组患者的围手术指标、并发症、血清白细胞介素（IL）-6和IL-10含量变化与CD133分子表达量变化。结果试验组的术中出血量、术后留置尿管天数、肠蠕动恢复时间与术后住院时间均明显少于对照组（P〈0.05）。试验组术后尿潴留、感染、肠梗阻与吻合口漏等总体并发症发生率明显均少于对照组（P〈0.05）。术后,2组患者的血清IL-6和IL-10含量较治疗前均明显下降（P〈0.05）,且试验组术后的血清IL-6和IL-10含量明显少于对照组（P〈0.05）。术后,2组患者的CD133分子表达量较治疗前明显升高（P〈0.05）,且试验组术后的CD133分子表达量明显高于对照组（P〈0.05）。结论腹腔镜下手术治疗结直肠癌能促进患者的康复,并发症少,对患者的创伤与应激反应的作用少,其机制可能在于能够有效地提高CD133分子的表达。Objective To investigate the effect of surgical treatment of colorectal cancer on CD133 molecule expression and its clinical significance. Methods One hundred twenty colorectal cancer patients were randomly divided into treatment group（ n = 60） and control group（ n = 60）. Treatment group was received laparoscopic surgical resection,and control group was given the traditional open surgery. Perioperative indicators,postoperative complications,serum interleukin（ IL）- 6 and IL- 10 content in the CD133 molecule expression variation were compared between the two groups. Results The blood loss,postoperative indwelling catheter days,bowel recovery time and postoperative hospital stay of treatment group were significantly less than those of control group（ P〈0. 05）. The postoperative overall complication rates of urinary retention,infection,bowel obstruction and anastomotic leak of treatment group were significantly less than the those in control group（ P〈0. 05）. The preoperative serum IL- 6 and IL- 10 contents betweenthe two groups showed no significant difference. The postoperative serum IL- 6 and IL- 10 contents all showed significant decreases（ P〈0. 05） with treatment group less than control group（ P〈0. 05）. After flow cytometry analysis,the postoperative CD133 molecules expressions in the two groups shown increased trend（ P〈0. 05）,while treatment group were significantly higher（ P〈0. 05）. Conclusion Laparoscopic surgery can promote the rehabilitation of patients with colorectal cancer. It has fewer complications and less trauma and stress response to the patients,which might be correlated with the increase of CD133 molecules expression.

关 键 词：腹腔镜手术 结直肠癌 CD133分子 免疫作用 应激因子 

分 类 号：R979.1[医药卫生—药品] R735.3[医药卫生—药学]