头孢匹胺组合物与头孢哌酮舒巴坦钠治疗儿童社区获得性肺炎的临床疗效  

Efficacy of cefpiramide composition and cefoperazone-sulbactam in treating community acquired pneumonia of children

作　　者：周奕[1] 温大科[2] 顾晓虹[2] 王军 李天宇[2] 

机构地区：[1]无锡市儿童医院药剂科,江苏省214023 [2]无锡市儿童医院儿科,江苏省214023 [3]宜兴市第二人民医院儿科

出　　处：《江苏医药》2015年第19期2304-2305,共2页Jiangsu Medical Journal

摘　　要：目的比较头孢匹胺组合物与头孢哌酮舒巴坦钠治疗儿童社区获得性肺炎的疗效。方法细菌性肺炎患儿90例,随机分为三组:A组使用头孢哌酮舒巴坦钠80mg/kg,B组使用头孢匹胺组合物50mg/kg,C组使用头孢匹胺50mg/kg;均以静脉滴注给药,每8小时1次。比较三组患儿的临床疗效。结果三组的临床有效率均为100%。B组体温恢复时间、肺部啰音消失时间和住院天数分别为(1.2±1.5)d、(4.4±2.3)d和(6.7±1.5)d,均明显短于A和C组的(1.8±1.8)d和(1.6±1.4)d、(5.9±3.6)d和(5.9±3.1)d和(10.2±3.5)d和(10.5±2.7)d(P<0.05)。结论头孢匹胺组合物与头孢哌酮舒巴坦钠治疗儿童细菌性肺炎均疗效显著,其中头孢匹胺组合物治疗显效更快,患儿住院时间更短,不良反应发生率低。Objective To compare the therapeutic effects of cefpiramide ,cefpiramide composition and cefoperazone‐sulbactam in children with community acquired pneumonia （CAP ） . Methods Ninty children with bacteria CAP were equally randomized into three groups of A （treated with cefoperazone‐sulbactam 80 mg/kg ） ,B （treated with cefpiramide composition 50 mg/kg ） and C （treated with cefpiramide 50 mg/kg） .The drug was infused intravenously three times per day .Clinical efficacy was compared .Results The overall effectiveness rate of three groups was 100% .The times for body temperature returning to normal ,disappearance of pulmonary rales and hospital stay were （1.2±1.5）days,（4.4±2.3）daysand（6.7±1.5）daysingroupB,whichwerelessthan（1.8±1.8） day s ,（1.6 ± 1.4 ） day s ,（5.9 ± 3.6 ） day s and （5.9 ± 3.1 ） day s ,（10.2 ± 3.5 ） day s ,（10.5 ± 2.7 ） day s in groups of A and C（P〈0 .05） .Conclusion Cefpiramide composition and cefoperazone‐sulbactam are all effective in the treatment of children with bacteria CAP ,among which cefpiramide composition is more effective in shortening the times for body temperature returning to normal ,disappearance of pulmonary rales and hospital stay and reducing adverse effects .

关 键 词：头孢匹胺组合物 头孢哌酮舒巴坦钠 社区获得性肺炎 儿童 

分 类 号：R725[医药卫生—儿科]