血清抵抗素水平对2型糖尿病合并高血压患者血压的影响（英文）  

Influence of serum resistin level on blood pressure in patients with type 2 diabetes mellitus complicated hypertension

作　　者：李玉 段敬柱[2] 王崇全[1] 陈相健[3] 

机构地区：[1]湖北医药学院附属太和医院心血管内科,湖北十堰442000 [2]湖北医药学院附属太和医院呼吸内科,湖北十堰442000 [3]南京医科大学第一附属医院心内科

出　　处：《心血管康复医学杂志》2015年第5期471-475,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：国家自然科学基金项目(81170220)~~

摘　　要：目的:研究血清抵抗素(SR)水平与2型糖尿病(T2DM)合并高血压患者血压的相关性。方法:选择T2DM合并高血压患者(T2DM合并高血压组)124例,单纯T2DM患者(单纯糖尿病组)85例,正常对象(正常对照组)71例纳入研究。根据血压水平,T2DM合并高血压组被进一步分为1级亚组(34例),2级亚组(43例)和3级亚组(47例)。取外周静脉血测量三组SR及其他指标水平。Logistic多元回归分析用来分析影响血压水平的危险因素。Kendall′s tau-b相关分析用来分析SR,空腹胰岛素,量化胰岛素敏感指数和胰岛素抵抗指数与血压水平的相关性。结果:与健康对照组比较,单纯糖尿病组和T2DM合并高血压组SR水平显著升高[(7.21±2.65)ng/ml比(19.87±3.67)ng/ml比(31.32±3.89)ng/ml],且T2DM合并高血压组的显著高于单纯糖尿病组的(P均<0.01)。Logistic多元回归分析表明SR水平是影响患者血压水平的独立危险因素(R2=0.087,P<0.05)。Kendall′s tau-b相关分析显示SR水平与高血压患者血压水平呈显著正相关(r=0.202,P=0.001);控制其余影响因素后,二者间仍然呈显著正相关(r=0.233,P=0.022)。结论:血清抵抗素水平是2型糖尿病合并高血压患者的危险因素,与其血压水平呈显著正相关。Objective： To study the correlation between serum resistin （SR） level and blood pressure in patients with type 2 diabetes mellitus （T2DM） complicated hypertension. Methods： A total of 124 patients with T2DM complicat- ed hypertension （T2DM ＋ hypertension group）, 85 patients with pure T2DM （pure DM group） and 71 normal sub- jects （normal control group） were enrolled. According to blood pressure level, T2DM ＋ hypertension group was further divided into stage 1 subgroup （n=34）, stage 2 subgroup （n=43） and stage 3 subgroup （n=47）. Peripheral venous blood was taken to measure levels of SR and other indexes in three groups. Logistic multi-factor regression a- nalysis was used to analyze the risk factors affecting blood pressure level. Kendall＇s tau-b correlation analysis was used to analyze the correlation among SR, fasting insulin, quantitative insulin sensitivity check index, homeostasis model-insulin resistance index and blood pressure level. Results： Compared with normal control group, there were significant rise in SR levels [ （7.21±2.65） ng/ml vs. （19.87±3.67） ng/ml vs. （31.32±3.89） ng/ml] in pure DM group and T2DM ＋ hypertension group, and that of T2DM ＋ hypertension group was significantly higher than that of pure DM group, P〈0. 01 all. Logistic multi-factor regression analysis indicated that SR level was an independent risk factor influencing blood pressure level of patients （R^2= 0. 087, P〈0.05）. Kendall＇ s tau-b correlation analysis indicated that SR level was significantly positively correlated with blood pressure level of patients with hypertension （r = 0. 202, P = 0. 001） ; after other influencing factors were controlled, the significant positive correlation still exis- ted between them （r=0. 233, P=0. 022）. Conclusion： Serum resistin level rise is risk factor of patients with type 2 diabetes mellitus complicated hypertension, and it significantly positively correlated with their blood pressure level.

关 键 词：糖尿病 2型 高血压 抵抗素 

分 类 号：R544.109[医药卫生—心血管疾病]