社区人群中性粒细胞/淋巴细胞比值与心血管病危险因素的关系  

Relationship between neutrophil to lymphocyte ratio and cardiovascular risk factors among community population

作　　者：郑东晗[1] 金元哲[1] 段志英[1] 林英子[1] 张学颖[1] 王婧如[1] 韩硕[1] 王国锋[1] 张一径[1] 

机构地区：[1]中国医科大学附属第四医院心血管病治疗中心,辽宁沈阳110032

出　　处：《心血管康复医学杂志》2015年第5期476-480,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：辽宁省科技计划项目(2009225010-8)~~

摘　　要：目的：研究社区35~64周岁居民中性粒细胞／淋巴细胞比值（N／L）与心血管病传统危险因素的关系。方法：2011年4月至2012年2月在沈阳市城区1884名居民（男548例，女1336例）中进行了心血管病及其相关疾病的基线情况调查。根据是否具有心血管危险因素，入选者被分为健康对照组（675例）和危险因素组（1209例）；根据具有的危险因素数量，危险因素组被进一步分为1个危险因素组（491例）、2个危险因素组（263例）和≥3个危险因素组（455例）。所有对象留取清晨血样、尿样检测血常规、尿常规、血糖、血脂等，比较分析各组的N／L比值。结果：在只有高血压、糖尿病、血脂异常、肥胖中任一危险因素的患者中，高血压和糖尿病患者的N／L水平显著高于健康对照组[1．55（1．15，1．95），1．60（1．21，2．07）比1．45（1．09，1．91）]，P均〈0．05，其余危险因素亚组与健康对照组间均无显著差异（P均〉0．05）。在危险因素亚组间，≥3个危险因素组的N／L水平显著高于2个危险因素组[1．57（1．16，2．04）比1．41（1．07，1．89），P〈0．051，其余各组问无显著差异（P〉0．05）。结论：中性粒细胞／淋巴细胞比值与高血压和糖尿病显著有关，且≥3个危险因素组的N／L水平显著高于2个危险因素组，N／L比值有助于评估心血管疾病风险。Objective： To study the relationship between neutrophil to lymphocyte ratio （N/L） and traditional cardio- vascular risk factors among community 35~64-year-old residents. Methods： A total of 1884 residents （548 males and 1336 females） from urban Shenyang city received baseline condition questionnaire on cardiovascular diseases and re- lated diseases from Apr 2011 to Feb 2012. According to presence of cardiovascular risk factors or not, subjects were divided into healthy control group （n = 675） and risk factor group （n = 1209） ; according to number of risk factors, risk factor group was further divided into one risk factor group （n = 491）, two risk factors group （n = 263） and 〉1/3 risk factors group （n = 455）. Morning blood sample and urine sample were retained to measure blood and urine rou- tine, blood glucose and blood lipid profile etc in all subjects. N/L was compared and analyzed among all groups. Re- suits： Among patients with only one of following risk factors [-hypertension, diabetes mellitus （DM）, dyslipidemia and obesity], N/L levels of patients with hypertension or DM were significantly higher than that of healthy control group [1.55（1.15, 1.95）, 1.60（1.21, 2.07） vs. 1.45（1.09, 1.91）], P〈0.05 both, and there were no significant difference between any other one risk factor group and healthy control group, P〉0.05 all. Among risk factor sub- groups, N/L level of ≥3 risk factors group was significantly higher than that of two risk factors group [1.57（1.16, 2.04） vs. 1.41（1.07, 1.89）, P〈0.05], and there was no significant difference between any other two groups （P〉 0.05）. Conclusion： N/L significantly related to hypertension or DM, and N/L level of ≥3 risk factors group was sig- nificantly higher than that of two risk factors group, N/L is helpful to assess risk of cardiovascular diseases.

关 键 词：淋巴细胞 心血管疾病 危险因素 

分 类 号：R540.9[医药卫生—心血管疾病]