静脉注射普罗帕酮治疗阵发性室上性心动过速的疗效  

Therapeutic effect of intravenous injection of propafenone on paroxysmal supraventricular tachycardia

作　　者：徐加红[1] 

机构地区：[1]江苏省如皋市人民医院心内科,江苏如皋226500

出　　处：《心血管康复医学杂志》2015年第5期561-564,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的：探讨静脉注射普罗帕酮对阵发性室上性心动过速患者的临床疗效及安全性。方法：选择我院心内科于2009年3月~2014年2月收治的80例阵发性室上性心动过速患者，利用随机数字表法分为普罗帕酮组（静脉给药）和胺碘酮组（静脉给药）。各40例。记录两组患者治疗前及治疗后24h的心率、转复窦性心律时间、临床总有效率及不良反应发生率。结果：两组组间总有效率无显著差异（P〉0．05）。与胺碘酮组比较，普罗帕酮组复律时间明显缩短[（18．9±3．2）min比（7．3±1．0）min]，治疗后24h心率明显降低[（99．6±8．4）次／min比（81．2±5．9）次／mini，P均〈0．05。结论：静脉注射普罗帕酮与胺碘酮治疗阵发性室上性心动过速的疗效相当，但普罗帕酮复律快，且能显著降低心率，安全性亦佳，值得在临床上推广。Ohjeetive： To explore therapeutic effect of intravenous injection of propafenone on patients with paroxys- mal supraventricular tachycardia （PSVT） and its safety. Methods： A total of 80 PSVT patients, who were treated in our department of cardiology from Mar 2009 to Feb 2014, were selected. According to random number table meth- od, they were randomly and equally divided into propafenone group （received propafenone intravenously） and amio- darone group （received amiodarone intravenously）. Heart rate, cardioversion time, clinical total effective rate and incidence rates of adverse reactions were recorded and compared between two groups before and 24h after treat- ment. Results： There was no significant difference in total effective rate between two groups, P〉0. 05. Compared with amiodarone group, there were significant reductions in cardioversion time [ （18. 9 ± 3.2） rain vs. （7.3 ± 1.0） minl, heart rate after treatment 24 h [（99.6 ± 8. 4） beats/min vs. （81.2 ±5.9） beats/mini in propafenone group, P〈0.05 both. Conclusion.. Intravenous injections of propafenone and amiodarone possess similar therapeutic effect on paroxysmal supraventricular tachycardia, but propafenone can achieve rapid cardioversion and reduce heart rate with satisfying safety, which is worth further extending,

关 键 词：心动过速 室上性 普罗帕酮 胺碘酮 

分 类 号：R541.71[医药卫生—心血管疾病]