5-羟色胺转运体基因多态性与冠心病合并抑郁相关性的Meta分析  

Genetic association of serotonin transporter gene polymorphisms with coronary heart disease and depression: a Meta-analysis

作　　者：崔青扬 丁建东[1] 李浩[1] 敖明强 

机构地区：[1]东南大学附属中大医院心内科,江苏南京210009

出　　处：《东南大学学报（医学版）》2015年第5期792-796,共5页Journal of Southeast University(Medical Science Edition)

摘　　要：目的：通过Meta分析综合评价5-羟色胺转运体（5-HTT）基因多态性与冠心病合并抑郁的关系，为冠心病合并抑郁的遗传背景提供进一步证据。方法：计算机检索 PubMed、Embase、Google 学术、Web of Science、中国生物医学文献数据库、CNKI、万方等数据库，依据选择标准收集所有相关病例对照研究，应用RevMan 5.2.5软件对符合条件的研究结果进行Meta分析。结果：有3篇文献纳入本研究，纳入本研究的人群总数为3230例，其中1179例为冠心病合并抑郁，不合并抑郁组的人群有2051例。分析显示，LL基因型在对照组中显示频率较高，可能是冠心病合并抑郁症的保护因子（ OR＝0.65，95％CI为0.50～0.83，P＝0.0006）。结论：5-HTT基因多态性与冠心病合并抑郁症存在关联，其中LL基因型可能为保护性因子。Objective： To evaluate the associations of 5-HTT gene polymorphism with depression and coronary heart disease by Meta-analysis and to provide evidence for the genetic background of depression and coronary heart disease.Methods：We conducted a comprehensive search for articles from PubMed, Embas, Google Scholar, Web of Science, Chinese BioMedical Literature, CNKI databases and Wanfang databases.All related case-control studies were collected and the results were analyzed by RevMan 5.2.5 software.Results：A total of 1 179 cases and 2 051 controls were collected from 3 studies.The analysis showed that LL genotype showed a higher frequency in the control group（OR=0.65,95%CI 0.50-0.83,P=0.000 6）, and it might be a protective factor of coronary heart disease with depression.Conclusion：Polymorphisms of 5-HTT gene have association with the depression and coronary heart disease, LL genotype may be a protective factor for the depression and coronary heart disease.

关 键 词：抑郁症 冠心病 5-羟色胺转运体基因 基因多态性 META分析 

分 类 号：R541.4[医药卫生—心血管疾病]