和解分消汤治疗急性肾损伤疗效观察  

Observation of Curative Effect of Hejie Fenxiao Decoction on Acute Kidney Injury

作　　者：张改华[1] 李深[1] 游梦祺 黄秋华[1] 赵宇[1] 王丽[1] 饶向荣[1] 齐文升[1] 

机构地区：[1]中国中医科学院广安门医院肾病科,北京100053

出　　处：《中国中医药信息杂志》2015年第10期31-34,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：中国中医科学院广安门医院科研基金(2011s241)

摘　　要：目的探讨和解分消汤治疗急性肾损伤湿热型患者的临床疗效。方法将68例患者按患者意愿分为治疗组和对照组。2组均予祛除诱因、对症治疗,治疗组加用和解分消汤,疗程均为30 d。观察2组患者肾功能指标(血肌酐、尿素氮、尿酸、白蛋白)和中医证候积分变化,比较2组肾功能恢复比例和终点事件发生情况。结果治疗14 d,2组血肌酐和肾小球滤过率均改善(P<0.05)。治疗30 d,2组肾功能恢复比例、肾脏替代率比较有明显差异(P<0.05);治疗组生存率高于对照组,但差异无统计学意义(P>0.05);2组终点事件发生率比较差异有统计学意义(P<0.05)。治疗14 d,2组中医证候积分比较差异有统计学意义(P<0.05)。结论和解分消汤联合基础治疗能较好改善患者的临床症状,恢复肾功能,减少肾脏替代及死亡的发生。Objective To investigate the clinical efficacy of Hejie Fenxiao Decoction on damp-heat patients with acute kidney injury(AKI). Methods Totally 68 patients were divided into the control group and the treatment group according to the patients' willings. Both groups were given treatment, such as elimination of the incentives and symptomatic treatment. Besides, patients of the treatment group accepted Hejie Fenxiao Decoction for 30 days. The changes of renal function indexes, such as serum creatinine(SCr), blood urine nitrogen(BUN), uric acid(UA), albumin(ALB) and integral of TCM syndrome, were observed, and recovery ratio and clinical endpoints were compared. Results SCr and e GFR of both group were improved on day 14(P < 0.05). After treatment, the renal function recovery ratio and renal replacement ratio in the two groups showed obvious differences(P <0.05);although survival rate of treatment group was higher than control group, it showed no statistical significance(P >0.05);clinical endpoints analysis of the two groups showed statistical significance(P <0.05). The difference of integrals of TCM syndrome between the two groups showed statistical significance(P <0.05) on day 14. Conclusion Hejie Fenxiao Decoction combined with basic regular Western medicine can better improve the clinical symptom, recover the renal function, and decrease the rate of renal replacement and death of AKI damp-heat patients.

关 键 词：和解分消汤 急性肾损伤 临床疗效 

分 类 号：R272.969.2[医药卫生—中医儿科学]