古方治疗中晚期原发性肝癌随机对照试验Meta分析  

Ancient Classical Prescriptions Treating Middle and Advanced Primary Liver Cancer:A Meta-analysis of Randomized Controlled Trials

作　　者：赵秀秀[1] 李博[1] 曲骞 郝腾[1] 刘维丽[1] 吴煜[1] 

机构地区：[1]中国中医科学院西苑医院,北京100091

出　　处：《中国中医药信息杂志》2015年第11期31-35,共5页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家"重大新药创制"创新药物研究开发技术平台建设(2012ZX09303-010-002);国家自然科学基金青年基金(81303151)

摘　　要：目的评价古方联合对症支持疗法治疗中晚期原发性肝癌的疗效。方法计算机检索Pubmed、Embase、SCI、Cochrane Liarary数据库及中国知识资源总库(CNKI)、中文科技期刊全文数据库(VIP)、中国生物医学文献数据库(CBM)、万方数据,收集古方治疗中晚期原发性肝癌的随机对照试验。结果共纳入17个研究,994例患者。结果显示,古方联合应用治疗中晚期原发性肝癌较单纯对症支持疗法近期有效率增加28%、生活质量稳定率增加23%、中医证候有效率增加29%及3个月、6个月和1年生存率分别增加16%,36.7%和58.5%、治疗后生活质量评分平均增加6.29分。结论古方联合对症支持疗法治疗中晚期原发性肝癌在近期有效率、生存率(3个月/6个月/1年)、生活质量、中医证候上优于单纯对症支持疗法。因证据强度不高,以上结论仍需要大样本、多中心、高质量的随机对照试验进一步验证。Objective To evaluate the efficacy of ancient classical prescriptions treating middle and advanced primary liver cancer. Methods Articles were searched from Pubmed, Embase, SCI, Cochrane Liarary and CNKI, VIP, Wan Fang Data, CBM databases. Randomized controlled trials about ancient classical prescriptions treating advanced primary liver cancer were collected. Results 17 studies were included, a total of 994 patients. The recent efficiency of ancient classical prescription combined with symptomatic therapy increased by 28% compared with single supportive and symptomatic therapy;the stable rate of life quality increased by 23%;the efficiency of TCM syndrome increased by 29%;the survival rates of 3 months, 6 months and 1 year increased by 16%, 36.7% and 58.5% respectively;the life quality score of later increased by 6.29 on average. Conclusion Ancient classical prescription combined with supportive and symptomatic therapy in advanced primary liver cancers is superior to single supportive and symptomatic therapy on recent efficiency, survival rate(3 months/6 months/1 year), quality of life and TCM syndrome. The conclusion of this study needs randomized controlled trials with larger samples, multicenter and high quality for further verification.

关 键 词：古方 支持对症疗法 中晚期原发性肝癌 随机对照试验 META分析 

分 类 号：R2-05[医药卫生—中医学] R273.57