紫癜清颗粒联合针刺治疗对HSP患者调节性T细胞的影响  

Effects of Zidianqing Particle Combined with Acupuncture on Tregs in the Treatment of Henoch-Schonlein Purpura Patients

作　　者：常亚娟[1] 张月[1] 刘虹颖[1] 张玲[1] 杨丰源[1] 郝晶[1] 苑海刚[1] 

机构地区：[1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《现代生物医学进展》2015年第24期4746-4750,共5页Progress in Modern Biomedicine

基　　金：黑龙江省自然科学基金项目(D201153);黑龙江中医药管理局(ZHY10-Z41)

摘　　要：目的:探讨紫癜清颗粒对过敏性紫癜(HSP)患者的临床疗效及外周血CD4+CD25+Foxp3+表达的影响。方法:纳入120例确诊为HSP患者,随机分为两组,治疗组予以紫癜清颗粒联合针刺治疗,对照组予以强的松联合扑尔敏治疗;两周为一个疗程,共观察4周,采用流式细胞术检测外周血CD4+CD25+Foxp3+的表达。结果:治疗组有效率与对照组相当(P>0.05),但复发率较对照组减低(P<0.01);治疗组治疗后患者外周血CD4+CD25+Foxp3+比例增高,与对照组治疗后患者外周血CD4+CD25+Foxp3+的表达相比,无统计学意义(P>0.05),但表达比例较对照组高。结论:紫癜清颗粒联合针刺治疗过敏性紫癜既可以明显改善患者临床症状,还能降低复发率;治疗后CD4+CD25+Foxp3+明显升高,说明调节性T细胞可能参与了HSP的发病,也可能是紫癜清颗粒联合针刺治疗HSP有效的原因。Objective： To investigate the clinical effect of the Zidianqing particle in the treatment of henoch-sch觟nlein purpura（HSP） and its effect on CD4＋CD25＋Foxp3＋expression in peripheral blood. Methods： 120 patients of HSP were randomly divided into two groups. The patients in treatment group were oral used Zidianqing particle combined with acupuncture, and the patients in control group were used prednisone combined with chlortrimeton. Two weeks was as a course of treatment, totally 4 weeks. The expression of CD4＋CD25＋Foxp3＋was detected by using flow cytometry. Results： The effective rate was similar between two groups（P〉0.05）, but the recurrence rate of treatment group was lower compared with control group（P〈0.01）; the proportion of CD4＋CD25＋Foxp3＋expression in peripheral blood was increased in treatment group, higher than that of control group, while it was no statistically significant compared with control group after treatment（P〉0.05）. Conclusions： Zidianqing particle combined with acupuncture could not only obviously improve the clinical symptoms of patients, but also reduce recurrence in the treatment of abdominal type Henoch-Sch觟nlein purpura; the proportion of CD4＋CD25＋Foxp3＋expression wasincreased in peripheral blood after treatment, suggesting that Tregs may be involved in the pathogenesis of HSP, and that may be the reason of effective treatment with Zidianqing particle in HSP.

关 键 词：过敏性紫癜 紫癜清颗粒 针刺 TREGS 

分 类 号：R554.6[医药卫生—血液循环系统疾病]