白细胞介素17在妊娠合并乙肝中的表达  

The Expression of IL-17 in the Placenta of Pregnant Women Infected by HBV

作　　者：张瑜[1] 陈萱[1] 林楠[2] 孙玉红[1] 吕楠[1] 

机构地区：[1]哈尔滨医科大学附属第二医院,黑龙江哈尔滨150086 [2]哈尔滨医科大学附属第四医院,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2015年第27期5309-5311,5328,共4页Progress in Modern Biomedicine

基　　金：黑龙江省卫生厅课题(G2004126);黑龙江省教育厅海外学人基金项目(G1153H14)

摘　　要：目的:观察白细胞介素17(Interleukin-17,IL-17)在乙肝孕妇和正常孕妇胎盘中表达差异来反映胎盘内的细胞免疫应答的情况,为外源性细胞因子在增强机体免疫、清除病毒及阻断和治疗HBV宫内感染提供新的科学依据。方法:选择择期剖宫产的足月妊娠妇女46例,其中血清HBs Ag(+)30例,血清HBs Ag(-)的对照组16例,采用免疫组化方法检测胎盘组织IL-17的表达。结果:IL-17主要表达在胎盘绒毛的合体滋养层细胞胞浆、毛细血管内皮细胞胞浆以及基质中。血清HBs Ab(+)孕妇与HBs Ab(-)孕妇比较,无显著差异(P>0.05),HBs Ag(+)乙肝孕妇与对照组的表达比较差异有统计学意义(P<0.05),HBe Ag(+)孕妇与HBe Ag(-)孕妇的表达比较差异有统计学意义(P<0.05)。结论 :IL-17在乙肝孕妇胎盘组织中的表达高于正常孕妇,IL-17的表达不但加强了机体的防御功能,且能促进炎性反应。Objective： To investigate the difference of interleukin-17（IL-17） expression between placenta of pregnant women infected by HBV and normal pregnant women. Methods： 46 women who was pregnant for 37-41＋6 weeks undergoing elective cesarean delivery were divided into two groups, 30 cases of HBs Ag（＋） and 16 cases of control group with HBs Ag（-）. Immunohistochemistry was used to examine the level of IL-17 in the placeta. Results： IL-17 was mainly expressed in the cytoplasm of syncytiotrophoblast, capillary endothelial cell cytoplasm and the matrix of the placental villi. There was no significant difference（P〉0.05） between HBs Ab（＋） pregnant women and HBs Ab（-） ones. Compared HBs Ag（＋） pregnant women with the control group there was significant difference（P〈0.05）.Expression of IL-17 in pregnant women with HBe Ag（＋） was statistically significant difference（P〈0.05） compared with HBe Ag（-） ones.Conclusions： IL-17 expression in the placenta of pregnant women combined with HBV infection was higher than normal pregnant women, which could strengthen the body’s defenses, and also promote inflammatory reaction.

关 键 词：白细胞介素17 乙型肝炎病毒 自身免疫 宫内感染 

分 类 号：R714.25[医药卫生—妇产科学] R722.131[医药卫生—临床医学]