骨质疏松标志物在评价类风湿关节炎骨代谢及侵蚀作用的临床研究  

Osteoporosis Markers in the Clinical Evaluation of Bone Metabolism and Erosion in Rheumatoid Arthritis

作　　者：孙倩[1] 李明芬 潘靖[1] 许铁[1] 迟伟群[1] 

机构地区：[1]哈尔滨医科大学附属第四医院检验科,黑龙江哈尔滨150001 [2]哈尔滨市第二医院检验科,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2015年第27期5329-5332,共4页Progress in Modern Biomedicine

基　　金：黑龙江省卫生厅项目(2010-121)

摘　　要：目的:探讨Ⅰ型胶原交联羧基氨基端肽(β-Crosslaps)和总骨1型前胶原氨基端延长肽(P1NP)及C-反应蛋白(CRP)在类风湿性关节炎骨质疏松发生与骨侵蚀程度评价中的作用。方法:运用电化学发光法对β-Cross Laps、P1NP进行定量检测。用胶乳散射比浊法进行CRP定量检测。将65例类风湿关节炎患者按有无骨质破坏分为早期组和非早期组,按活动性分为缓解组与活动组,按骨影像学显示分为骨侵蚀组与非骨侵蚀组。并取30例健康体检者作为对照组。结果:三种标志物在早期RA组与非早期RA组之间及在活动组与缓解组、骨侵蚀组与非骨侵蚀组比较具有显著差异,差异有统计学意义(P<0.01)。结论:β-Cross laps、P1NP、CRP三种骨质疏松标志物可以用作评价RA骨代谢水平和骨侵蚀程度的良好指标,并还可以运用于疗效监测,有较好的临床应用价值。Objective： To discuss the clinical value of applying the β-Crosslaps, P1 NP and CRP in estimating the occurrence of osteoporosis and bone eroding in rheumatoid arthritis（RA）. Methods： The levels of β-Crosslaps, P1 NP, CA15-3 were examined by the electrochemi-luminescence method, and the concentration of CRP was detected by latex nephelometry. 65 RA patients and 30 healthy volunteers were enrolled in this study. RA patients were divided into early stage group and non-early group, bone erosion group and non-bone erosion group, bone erode group and non-bone erode group according to the bone destruction, the bone imaging and the results of bone imageology respectively. Results： The levels of these three markers were significantly different among these groups according to the three classification methods（P〈0.01）. Conclusions： The concentrations of β-Crosslaps,P1 NP and CRP might be potential biomarkers for evaluating bone metabolism and bone eroding in RA. And they could be used as a therapeutic monitor with an excellence clinical application value.

关 键 词：骨质疏松标志物 类风湿性关节炎 骨代谢 骨侵蚀 

分 类 号：R446.61[医药卫生—诊断学] R593.22[医药卫生—临床医学]