医用多孔钛的研究进展  

Progress in Biomedical Porous Titanium Research

作　　者：夏卓玙 孙晶晶[1] 李建卫[1] 李莎莎[1] 龙洁[1] 

机构地区：[1]四川大学华西口腔医学院,四川成都610041

出　　处：《现代生物医学进展》2015年第27期5380-5383,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(31070833);四川科技支撑计划基金项目(2009SZ0139;2010GZ0225;2011GZ0335)

摘　　要：钛及钛合金由于其优良的抗腐蚀性、生物相容性、低密度和高强度等特点,已广泛应用于承力部位的骨修复,但是如何促进植入体与骨组织界面的有效结合仍是技术瓶颈,一方面由于植入体的弹性模量与骨组织不匹配,由此产生的应力屏蔽易导致植入体松动,另一方面植入体缺乏骨诱导作用,导致材料骨界面之间不能形成有效的生物化学结合。近来,具有表面优化处理的新型生物医用多孔钛材料通过引入孔隙的方法,使其与骨组织的力学性能相匹配,并且应用活化改性技术,使其具有生物活性,成为目前骨替代材料的研究热点和发展方向。本文简要总结了多孔钛材料在力学性能、生物相容性、制备方法和表面改性等方面的研究进展,强调在保证其多孔优势性能的前提下,通过生物活性因子的引入,进一步改善其生物相容性,提高结合力,延长植入体的寿命,使其具有诱导成骨功能,是新型多孔钛材料的发展趋势。Titanium and titanium alloys have been widely used in bone repair under load-bearing conditions due to their excellent corrosion resistance, biocompatibility, low density and high strength properties. However, the effective combination of the material and the bone remains a problem. One reason for that is the mismatch of elastic modulus between material and the nature bone,this leads to the stress shielding and finally result in the loosening of the implants. Another defect is that the material usually fails to attach to bone through biochemical bonding for lacking of osteoinductive ability. Recently, a new type of biomedical porous titanium material, which with introducing the pores into the whole material and the application of the surface modification, has became the research focus and developing trend of bone substitute materials. This article briefly summarizes the mechanical property, biological compatibility, preparation method and surface modification of the porous titanium material. On the premise of guarantee its porous advantage, to futher improve the compatibility and prolong the service life will be the development trend of new porous titanium materials.

关 键 词：多孔钛 生物材料 表面改性 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程]