N-myc蛋白和非编码RNA在神经母细胞瘤中的研究进展  

Progress of N-myc and Noncoding RNAs in Neuroblastoma

作　　者：韩宇娟 彭红霞 廖旺 颜慕霞 

机构地区：[1]广州市妇女儿童医疗中心内科部,广东广州510623 [2]广州市妇女儿童医疗中心血液肿瘤科,广东广州510623

出　　处：《现代生物医学进展》2015年第27期5397-5400,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81272310);广东省自然科学基金项目(S2012020011020)

摘　　要：神经母细胞瘤是儿童外周神经系统的肿瘤。在近20%的神经母细胞瘤病例中发现有原癌基因MYCN的扩增和过表达现象。近几年发现MYCN基因编码的N-myc蛋白,不仅能够调控多种非编码RNA的表达,而且也受非编码RNA的调控。mi RNA是在神经母细胞瘤中研究最广泛的非编码RNA,近年来研究发现N-myc蛋白对于绝大部分mi RNA起抑制作用,如mir-184、mir-542-5p等,仅对少数mi RNA起诱导表达的作用,如mir-17-92基因簇、mir-9、mir-421等。N-myc蛋白不仅对mi RNA的表达起调节作用,而且也调控其它lnc RNA的表达,如T-UCR、NDM29、linc00467、MALAT1。有趣的是,N-myc蛋白和mi RNA之间的作用是相互的,它们可以双向调节,其调控网络也是复杂的。mi RNA能够靶向MYCN,同时MYCN也能够调控mi RNA。该文对神经母细胞瘤中N-myc蛋白和非编码RNA间的相互影响,以及两者之间的关系对神经母细胞瘤的发生有何作用作一综述。Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Amplification and overexpression of the MYCN proto-oncogene occurs in approximately 20% of neuroblastomas. MYCN encodes the transcriptional regulator N-myc. In recent years, it has become clear that N-myc not only modulates the expression of several classes of noncoding RNAs, but noncoding RNAs have also been documented to modulates N-myc expression. Micro RNAs are the most widely studied noncoding RNA molecules in neuroblastoma. Growing evidences show that N-myc predominantly acts repressively on the most mi RNA composition（i.e., mir-184,mir-542-5p, etc.）, only induces less mi RNA expression（i.e., mir-17-92 cluster, mir-9, mir-421, etc.）. The N-myc protein is not only considered as an important regulator of several mi RNAs, but also regulates the expression of long noncoding RNAs such as T-UCR、NDM29、linc00467 and MALAT1. The interaction between N-myc and mi RNAs is mutual and complex, they can regulate to each other.MYCN can regulate the expression of mi RNAs, but itself is targeted by mi RNAs. This review summarizes the current knowledge about the interplay between N-myc and noncoding RNAs in neuroblastoma and how this contributes to neuroblastoma tumorigenesis.

关 键 词：神经母细胞瘤 N-MYC 非编码RNA MIRNA lncRNA 

分 类 号：Q75[生物学—分子生物学] Q78