血胱抑素C及尿素氮对老年Ⅱ型心肾综合征患者的检测价值  

Detection value of serum cystatin C and urea nitrogen in elderly patients with type 2 cardiorenal syndrome

作　　者：孙媛媛[1] 常渭琴[1] 郭少敏[1] 

机构地区：[1]西北农林科技大学医院内科,陕西杨凌712100

出　　处：《临床医学》2015年第8期1-3,共3页Clinical Medicine

摘　　要：目的探讨血胱抑素C及血尿素氮（BUN）对老年Ⅱ型心肾综合征患者的检测意义。方法选取2013年10月至2014年6月因慢性心力衰竭住院的老年患者76例为研究对象,进一步将患者分成单纯心力衰竭组和心肾综合征组,同时选择30例健康老年人为对照组,比较各组间血胱抑素C、血肌酐及血尿素氮水平变化;心肾综合征组据NYHA心功能分级进一步分为Ⅱ-Ⅳ级组,比较各亚组间血胱抑素C、血肌酐、血尿素氮水平变化;心肾综合征组据BUN水平进一步分为BUN〈7 mmol/L组及BUN≥7 mmol/L组,比较两组间的再入院率及病死率。结果血胱抑素C水平在单纯心力衰竭组和心肾综合征组显著高于对照组,而心肾综合征组显著高于单纯心力衰竭组,随心肾综合征组心功能分级的升高,血胱抑素C、血肌酐水平逐渐升高而血尿素氮水平在心功能Ⅱ级、Ⅲ级两组间比较差异未见统计学意义,BUN〈7 mmol/L和BUN≥7 mmol/L两组间的再入院率及病死率比较差异有统计学意义。结论血胱抑素C是一个早期诊断老年Ⅱ型心肾综合征患者的敏感指标,血尿素氮可方便预测老年Ⅱ型心肾综合征患者的预后,值得临床推广应用。Objective To investigate the detection value of serum cystatin C and urea nitrogen in elderly patients with type 2cardiorenal syndrome. Methods Seventy-six elderly patients with chronic heart failure treated from October 2013 to June 2014 were investigated. All of them were divided into pure heart failure group and cardiorenal syndrome group. At the same time,thirty old healthy people were chosen as control group. Serum cystatin C,creatinine and urea nitrogen were compared among these three groups. Furthermore cardiorenal syndrome group was divided into three sub-groups： HF grade Ⅱgroup,HF grade Ⅲ group and HF grade Ⅳgroup according to NYHA cardiac function classification. Similarly,serum cystatin C,creatinine and urea nitrogen were also compared among the sub-groups. At last,cardiorenal syndrome was divided into two groups： BUN 〈7mmol / L group and BUN≥7 mmol / L group according to the level of blood urea nitrogen. The re-admission rate and death rate was observed and compared between the two groups. Results Serum cystatin C in cardiorenal syndrome group was significantly higher than that in the pure heart failure group,and the difference was statistically significant（ P〈0. 05）,while that in the two groups was significantly higher than that in the control group. The concentration of serum cystatin C and creatinine were increasing with the rising of group grade,but the difference of the concentration of urea nitrogen in HF grade Ⅱgroup and Ⅲ group was not statistically significant（ P〈0. 05）.The differences of the re-admission rate and death rate in the BUN〈 7 mmol / Lgroup and BUN≥7 mmol / L group were statistically significant（ P〈0. 05）. Conclusion Serum cystatin C is an early diagnosis indicator in elderly patients with type 2 cardiorenal syndrome,while serum urea nitrogen can predict the prognosis. They are worth to be applied and extended in the clinics.

关 键 词：心肾综合征 心力衰竭 血胱抑素C 血尿素氮 

分 类 号：R541.6[医药卫生—心血管疾病]