绝经前后尿酸与代谢综合征的关联分析  

The relationship between serum uric acid concentration and metabolic syndrome according to different menopausal status

作　　者：钱巧霞[1] 周敬茹 丁月[1] 杨亚军[1,2] 金力[1,2] 王笑峰[1,2] 王久存[1,2] 

机构地区：[1]复旦大学生命科学学院现代人类学教育部重点实验室,上海200438 [2]复旦大学泰州健康科学研究院,泰州225300

出　　处：《复旦学报（医学版）》2015年第5期579-583,共5页Fudan University Journal of Medical Sciences

基　　金：上海市科委基础研究重大项目(11DJ1400102);国家科技支撑重点项目(2011BAI09B00)~~

摘　　要：目的分析比较绝经前、后女性血清尿酸水平与代谢综合征(metabolic syndrome,MS)的关系。方法采取多阶段整群随机抽样的方法于2013年抽取江苏省泰兴市根思乡、姚王镇等12个自然村,调查40~65岁的女性3 187人,其中未绝经1 457人,已绝经者1 730人。分别分析未绝经组和绝经组尿酸水平与MS的关系。结果 MS的总患病率为15.34%,绝经女性为18.68%,明显高于未绝经女性(11.41%,P<0.001)。MS的患病率均随尿酸水平的升高而升高(趋势检验,P<0.001),同一尿酸水平时绝经女性的MS患病率高于未绝经女性。多因素Logistic回归分析结果显示无论是否绝经,尿酸均是MS的独立危险因素,但同一尿酸水平时绝经女性患的MS患病风险高于未绝经女性。结论绝经对尿酸和MS的关系具有"修饰"作用,绝经后尿酸对MS的风险作用有所增加。Objective To compare the relationship between uric acid and the metabolic syndrome （MS） according to different menopausal status. Methods In 2013, 3 187 women age ranged from 40 to 65 and including 1 457 premenopausal women and 1 730 postmenopausal women were enrolled from 12 villages of Gensi township and Yaowang township of Taixing city though three-stage stratified sampling method. The study subjects were divided into premenopausal women group and postmenopausal women group for the analysis on the relationship between serum uric acid concentration and metabolic syndrome. Results The overall prevalence of MS was 15.34 ~, while in the premenopausal women it was 18.68 ~, which was significantly higher than premenopausal women （11.41% ,P^0. 001）. The prevalence of MS was increasing as the level of serum uric acid （P〈0. 001, trend test）, however the prevalence was higher among postmenopausal women. Logistic regression analysis showed that Uric acid was an independent factor for MS in neither postmenopausal women nor premenopausal women. However, postmenopausal women had greater risk of MS than the premenopausal women with the same uric acid level. Conclusions Menopause has a ＂modified＂ effect on the relationship between uric acid level and MS, and menopause would increase the risk effect of uric acid to MS.

关 键 词：绝经 代谢综合征 尿酸 

分 类 号：R589[医药卫生—内分泌]