不同剂量瑞舒伐他汀对急性心肌梗死患者心功能的影响  

Study on effect of different dosages of rosuvastatin on cardiac function in patients with acute myocardial infarction

作　　者：赵莉[1] 王晨霞[1] 高智耀[1] 

机构地区：[1]延安大学附属医院心血管内科,陕西延安716000

出　　处：《临床和实验医学杂志》2015年第20期1698-1700,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨不同剂量的瑞舒伐他汀在治疗急性心肌梗死患者时对患者心功能的影响。方法选取2013年5月至2015年4月入院的未行经冠状动脉介入治疗的急性心肌梗死患者84例,随机分为三组,对照组20例,瑞舒伐他汀常规剂量治疗组32例,瑞舒伐他汀大剂量组32例。对照组给予常规治疗,每日于睡前给予安慰剂10 mg。治疗组瑞舒伐他汀常规剂量除常规治疗外加用瑞舒伐他汀10 mg,每日一次于睡前服用;瑞舒伐他汀大剂量组外加用瑞舒伐他汀20 mg。于治疗后的1周、12周检测三组患者的脑钠素(BNP)水平、超敏C反应蛋白(hs-CRP)的含量。检测三组患者的心功能指标左心室射血分数(LVEF)、左室舒张期末内径(LVEDD)、左室收缩期末内径(LVESD)。结果治疗1周后,三组患者的BNP水平、hs-CRP含量以及超声学检测指标比较,差异无统计学意义(P>0.05);治疗12周后,三组患者BNP水平、hs-CRP含量均较第1周有明显的降低,且大剂量组降低更明显,三组患者差异具有统计学意义(P<0.05)。治疗12周后,三组患者超声学检测指标较第1周有明显的变化,LVEF明显升高,LVEDD、LVESD明显降低,其中大剂量组尤为显著,三组进行比较,差异具有统计学意义(P<0.05)。结论采用大剂量瑞舒伐他汀长期治疗急性心肌梗死患者能够抑制可能发生的相关炎症反应,显著地抑制左心室的扩张,有效地改善心功能。Objective To explore the effect of different dosages of rosuvastatin on heart function in treatment of patients with acute myocardial infarction. Methods A total of 84 cases of acute myocardial infarction during May 2013 to April 2015 were randomly divided into three groups,20 patients in control group,32 patients in rosuvastatin conventional dosage group and 32 patients in high dosage rosuvastatin group. Patients in control group received conventional treatment,with daily placebo 10 mg at bedtime. Patients in rosuvastatin treatment group were given with conventional dosage of rosuvastatin 10 mg,once daily at bedtime in addition to conventional treatment; and patients in high- dosage rosuvastatin group were given with rosuvastatin 20 mg daily. The serum levels of brain natriuretic peptide（ BNP） and high- sensitivity C- reactive protein（ hs- CRP） were detected in patients of these three groups after treatment for 1 week and 12 weeks. The cardiac function as left ventricular ejection fraction（ LVEF）,left ventricular end- diastolic inner diameter（ LVEDD） and left ventricular end- systolic inner diameter（ LVESD）were detected inpatients of these three groups. Results One week after treatment,serum levels of BNP and hs- CRP and ultrasonicdetection index were examined in patients of these 3 groups,and the difference was not statistically significant（ P〈0. 05）. In comparison with 1 week and 12 weeks after treatment,the levels of BNP and hs- CRP in patients ofthese three groups were significantly reduced,and the degree of reduction in patients of high- dosage group was more obvious,and the difference was statistically significant（ P〈0. 05）. After treatment for 12 weeks,LVEF wassignificantly increased,and LVEDD and LVESD were significantly decreased,and these were particularly significant in patients of high- dosage group,and the difference was statistically significant（ P〈0. 05）. Conclusion The long termhigh- dosage rosuvastatin treatment in patients with AMI can suppress the inflamma

关 键 词：急性心肌梗死 瑞舒伐他汀 剂量 心功能 

分 类 号：R542.22[医药卫生—心血管疾病]