响应曲面法优化原花青素柔性纳米脂质体的制备  

Optimization of the preparation of procyanidin deformable liposome by response surface

作　　者：韩阳[1] 付艳秋[2] 陈仁财[2] 李蒙[2] 韩静[2] 

机构地区：[1]辽宁中医药大学药学院,沈阳110847 [2]沈阳药科大学制药工程学院,沈阳110016

出　　处：《中南药学》2015年第9期926-929,共4页Central South Pharmacy

摘　　要：目的采用薄膜分散-超声法制备原花青素柔性纳米脂质体。方法以包封率为指标,采用响应面分析法设计试验,优化原花青素柔性纳米脂质体的制备工艺。结果原花青素柔性纳米脂质体最佳工艺参数为超声时间9 min,大豆卵磷脂与Tween 80的质量比10:1、大豆卵磷脂与药物的质量比17:1,在此优化条件下,测得的包封率为80.93%,平均粒径为(150.6±11)nm,zeta电位为(-23.76±2.3)m V,具有较好的体外缓释作用和较高的体外透皮性。结论响应曲面优选的原花青素柔性纳米脂质体的制备工艺实用可行。Objective To prepare procyanidins deformable liposome by membrane dispersion-ultrasound method. Methods The preparation was optimized with Box-Behnken design. Results The optimal conditions were as follows： ultrasound for 9 min, soya bean lecithin-Tween 80 ratio 10 ：1, and soya bean lecithin-procyanidin ratio 17 ：1. Under these conditions the encapsulation efficiency of procyanidin deformable liposome were 80.93%, the average size and zeta potential were（150.6±11） nm and（- 23.76±2.3） m V. It greatly prolonged the drug release and high penetration rate. Conclusion The preparation of procyanidin deformable liposome by response surface is practicable and feasible.

关 键 词：原花青素 柔性纳米脂质体 响应曲面法 体外缓释 透皮吸收 

分 类 号：TQ461[化学工程—制药化工]