喷雾型鼻腔过敏原阻隔剂对干燥性鼻炎的疗效观察  

Observation of the efficacy of allergen blocking nasal spray in patients with rhinitis sicca

作　　者：陈建军[1] 周玥[1] 王彦君[1] 张丽[1] 檀惠芳[1] 施秋梅[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院耳鼻咽喉科,武汉430022

出　　处：《临床耳鼻咽喉头颈外科杂志》2015年第19期1698-1700,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：十二五科技计划支撑项目(No:2014BAI07B04)

摘　　要：目的:研究喷雾型鼻腔过敏原阻隔剂联合生理性海水及桃金娘油对干燥性鼻炎的治疗效果。方法:对临床上拟诊为干燥性鼻炎患者,分为鼻阻隔剂+生理海水组(使用鼻阻隔剂联合生理性海水及桃金娘油)和生理海水组(使用生理性海水及桃金娘油)各30例,共治疗观察2周。对其主观干燥感VAS得分、客观体征得分及使用不适感进行对比。结果:鼻阻隔剂+生理海水组及生理海水组在治疗2周后,其主观干燥感及客观体征均明显改善。其中,鼻阻隔剂+生理海水组较生理海水组改善更为显著(主观干燥感VAS得分:P<0.01;客观体征得分:P<0.05)。鼻阻隔剂使用仅2例诉轻微不适。结论:喷雾型鼻腔过敏原阻隔剂联合生理性海水及桃金娘油对干燥性鼻炎有较显著的治疗效果。Objective：To observe the efficacy of allergen blocking nasal spray （ABNS）, combined with seawater spray （SS） and myrtol standardized capsules （MSS）, in patients with rhinitis sicca. Method：Patients diagnosed as rhinitis sicca were randomly divided into 2 groups： ABNS＋SS group and SS group. In ABNS＋SS group, patients used ABNS and SS four times per day and MSS twice per day. In SS group, patients used the same medicine except ABNS. Both group were observed for 14 days. The visual analog scale （VAS） of dryness, the endoscopy evaluation score （EES） and the tolerability of the spray were compared between the 2 groups. Result：There were 30 patients included in each group. The VAS and EES were improved in both groups after 2 weeks＇treatment. The improvement of VAS and EES in ABNS＋SS group was significantly superior to SS group （VAS： P〈0.01, EES： P〈0.05）. There were only 2 patients complaint of slight discomfort when using ABNS, which did not disturb the treatment. Conclusion：There is good efficacy of allergen blocking nasal spray （ABNS）, combined with seawater spray （SS） and myrtol standardized capsules （MSS）, in patients with rbinitis sicca.

关 键 词：鼻炎 喷雾型鼻腔过敏原阻隔剂 生理性海水鼻喷剂 桃金娘 

分 类 号：R765[医药卫生—耳鼻咽喉科]