N-正丁基苦参醇大黄酸酯的合成  

Synthesis of N-n-Butyl Matrinol Rheinate

作　　者：黄骏凯 吴亚先[1] 何黎琴[1] 

机构地区：[1]安徽中医药大学药学院,安徽合肥230031

出　　处：《化学世界》2015年第7期420-423,共4页Chemical World

基　　金：安徽省教育厅自然科学重点科研项目(KJ2013A168)

摘　　要：以苦参碱为原料,通过碱水解开环,溴代正丁烷丁基化得到N-正丁基苦参酸丁酯,经四氢铝锂还原得到N-正丁基苦参醇。大黄酸酰氯化后,与N-正丁基苦参醇反应,得到N-正丁基苦参醇大黄酸酯。目标化合物的化学结构经红外光谱、核磁共振氢谱及质谱确证。目标化合物收率达59.2%。Matrine was reacted with sodium hydroxide giving the hydrolytic ring-opening acid, which was first reacted with N-n-butyl bromide to yield N-butyl matrinate and derivative matrinic then reducted with lithium aluminum hydride to give N-n-butyl matrinol. Rhein was reacted with thionyl chloride to get rhei noyl chloride, which was reacted with N-n-butyl matrinol to yield N-n-butyl matrinol rheinate. The chemi cal structure of the target compound was confirmed by MS, IR, and 1H NMR spectra. The yield of N-n butyl matrinol rheinate was 59.2%.

关 键 词：苦参碱 大黄酸 合成 

分 类 号：R284[医药卫生—中药学]