甲基强的松龙冲击治疗儿童过敏性紫癜的临床疗效  

Clinical efficacy of methylprednisolone pulse therapy in treating Henoch-Schoenlein purpura in children

作　　者：李燕林[1] 王永清[1] 朱迪卿[1] 周益平[1] 

机构地区：[1]常州市第一人民医院(苏州大学附属第三医院)儿科,江苏省213000

出　　处：《江苏医药》2015年第18期2159-2161,共3页Jiangsu Medical Journal

摘　　要：目的探讨甲基强的松龙(MP)冲击治疗儿童过敏性紫癜(HSP)的临床疗效。方法 HSP患儿40例随机分为两组:对照组18例,给予常规治疗,包括抗组胺及防治感染等治疗;治疗组22例,在常规治疗基础上加用MP冲击治疗:输注MP 5-15mg·kg-1·d-1,连用3d后口服强的松,并于1周内减量渐停。应用ELISA双抗体夹心法检测治疗前后血清IL-6和IL-8表达;比较两组疗效。结果治疗组皮疹、腹痛、消化道症状和关节肿痛消失以及肾损害恢复时间均短于对照组(P<0.05或P<0.01);治疗后,治疗组血清IL-6和IL-8水平低于对照组[(12.02±4.81)ng/ml vs.(17.31±8.47)ng/ml和(10.61±4.66)ng/ml vs.(14.74±5.20)ng/ml](P<0.05)。结论早期应用MP冲击治疗儿童过敏性紫癜安全、有效。Objective To investigate the clinical efficacy of methylprednisolone （MP） pulse therapy in the treatment of Henoch-Schoenlein purpura（HSP） in children .Methods Forty children with HSP were randomly divided into two groups of C（treated with conventional antihistamines and antibiotics ,18 cases） and M（conventional treatment plus MP pulse therapy ,22 cases） .The MP pulse therapy was performed with an infusion of MP 5-15 mg·kg-1·d-1 for three days and oral prednisone thereafter ,which was given gradually in a reduced dose and stopped within one week .Serum levels of IL-6 and IL-8 were detected by ELISA before and after treatment .Clinical efficacy was compared between two groups .Results The times for the disappearance of skin rash ,gastrointestinal tract and osteoarticular syndromes ,and recovery of renal damage were shorter in group M than those in group C （P〈0 .05 or P〈0 .01） .Serum levels of IL-6 and IL-8 after treatment were lower in group M than those in group C[（12.02 ± 4.81） ng/ml vs .（17.31 ± 8.47） ng/ml and （10.61 ± 4.66） ng/ml vs . （14.74 ± 5.20） ng/ml]（P〈0 .05） .Conclusion Early use of MP pulse therapy is effective and safe in the treatment of children with HSP .

关 键 词：过敏性紫癜 甲基强的松龙 

分 类 号：R725[医药卫生—儿科]