甲状腺激素水平与2型糖尿病预后的关系  

Research on the Relationship between THS and Type II Diabetes Prognosis

作　　者：朱胜金[1] 杨丹[1] 莫阳[1] 胡爱妮 

机构地区：[1]贵阳中医学院第二附属医院检验科,贵州贵阳550001

出　　处：《贵阳医学院学报》2015年第11期1233-1235,共3页Journal of Guiyang Medical College

摘　　要：目的:探讨2型糖尿病(T2DM)患者血清甲状腺激素水平与糖尿病病情的关系。方法:178例T2DM患者作为糖尿病组,同时期117例健康体检人群作为对照组,分别采集糖尿病组入院时及对照组体检时清晨空腹静脉血4 m L,采用化学发光法检测游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)及促甲状腺激素(TSH)水平,采用免疫比浊法检测血清糖化血红蛋白(Hb A1c)水平;T2DM患者按Hb A1c水平和并发症再次分组,比较各组间FT3、FT4及TSH改变。结果:糖尿病组与正常对照组比较,FT3水平明显降低(P<0.01),FT4、TSH水平变化不明显(P>0.05);糖尿病患者随着Hb A1c水平增加,仅FT3呈下降趋势,组间比较差异有统计学意义(P<0.05);糖尿病并发症患者FT3水平显著低于无并发症患者(P<0.05或P<0.01)。结论:T2DM患者常伴有FT3水平降低,尤其对血糖控制不佳和有并发症的患者,FT3降低更明显。Objective： To investigate the relationship between Type 2 diabetes mellitus with thyroid hormone（ FT3、FT4、TSH） level change. Methods： A total of 178 patients with type 2 diabetes as diabetes group,117 healthy people as control group. Extracting venous blood of 2 groups,using chemiluinescence detection of serum thyroid hormone levels. Comparing two groups free three iodine thyroid glycine（ FT3）,free thyroxine（ FT4） and thyroid stimulating hormone（ TSH） changes; in patients with type 2 diabetes adopting immunoturbidimetric assay to detect Hb A1 c level. T2 DM patients will be regrouped according to Hb A1 c level and complications,in order to compare changes of FT3,FT4 and TSH. Results： Comparing Type 2 diabetes group with normal control group,FT3 level significantly decreased（ P〈0. 01）; no obvious difference was found between FT4 and TSH levels（ P〉0. 05）. With the increase of concentration of Hb A1 c,only FT3 level decreased（ P〈0. 05 or P〈0. 01）,FT3 level of diabetes complication group was obviously lower than no complication group（ P〈0. 05 or P〈0. 01）.Conclusion： Patients with type 2 diabetes often show decreased FT3 level,and patients with poor control of blood sugar and complications will lead obvious FT3 decrease.

关 键 词：游离三碘甲状腺原氨酸 糖尿病 非胰岛素依赖型 甲状腺激素类 糖化血红蛋白 并发症 

分 类 号：R587.1[医药卫生—内分泌]